SH3GL2 and DLGAP4

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		SH3GL2	DLGAP4
Description		SH3 domain containing GRB2 like 2, endophilin A1	DLG associated protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Early Endosome Cytosol Plasma Membrane Cell Junction Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm Basal Dendrite Photoreceptor Ribbon Synapse Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Presynaptic Cytosol	Plasma Membrane Neuromuscular Junction Glutamatergic Synapse Cholinergic Synapse Postsynaptic Specialization
	Molecular Function	Protein Binding Protein C-terminus Binding Lipid Binding Protein Kinase Binding Identical Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Signal Transduction Central Nervous System Development Negative Regulation Of Gene Expression Synaptic Vesicle Uncoating Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Neuron Projection Development Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Lipid Tube Assembly Membrane Organization Dendrite Extension Membrane Tubulation Membrane Bending Vesicle Scission Positive Regulation Of Membrane Tubulation Negative Regulation Of Maintenance Of Permeability Of Blood-brain Barrier Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Clathrin-dependent Endocytosis	Signaling
Pathways		Retrograde neurotrophin signalling Retrograde neurotrophin signalling EGFR downregulation MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Cerebral cortical growth ( 29682794) Cognitive performance ( 19734545) FEV1 ( 30804560) Heart failure ( 20445134) Lung function (FVC) ( 30804560) Midgestational circulating levels of PBDEs ( 28235828) Multiple sclerosis ( 19010793) Myopia ( 27182965) Obesity-related traits ( 23251661) Parkinson's disease ( 22451204 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pursuit maintenance gain ( 29064472) Small cell lung carcinoma ( 28604730) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		51 interacting genes: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 FBXO32 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL3 SH3KBP1 SLC17A7 SYNJ1 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC	15 interacting genes: BIN1 DLG1 DLG3 DLG4 EXOC4 GRIN1 GRIN2D PLP2 PPP1R1B SH3GL2 SHANK2 SHANK3 SORBS2 SYNGAP1 UBC
Entrez ID		6456	22839
HPRD ID		05125	16826
Ensembl ID		ENSG00000107295	ENSG00000080845
Uniprot IDs		Q7Z376 Q99962	A0A0B4J2C2 Q9Y2H0
PDB IDs		1X03 1X04 2D4C 2DBM
Enriched GO Terms of Interacting Partners?
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