HIF3A and EGLN3

Number of citations of the paper that reports this interaction (PubMedID 15474027)
27

Data Source:
HPRD (in vitro)

		HIF3A	EGLN3
Description		hypoxia inducible factor 3 subunit alpha	egl-9 family hypoxia inducible factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Mitochondrion Cytosol Plasma Membrane Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Dimerization Activity	Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity
	Biological Process	Angiogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia	Response To Hypoxia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Hydroxylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Proliferation Regulation Of Neuron Apoptotic Process Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Pathways		Regulation of gene expression by Hypoxia-inducible Factor Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Transcriptional regulation of pluripotent stem cells Neddylation	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs			Vitamin C Roxadustat
Diseases
GWAS		Free cholesterol levels in medium VLDL ( 29084231) Medium VLDL particle concentration ( 29084231) Phospholipid levels in large VLDL ( 29084231) Phospholipid levels in medium VLDL ( 29084231) Phospholipid levels in small VLDL ( 29084231) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Small VLDL particle concentration ( 29084231) Total cholesterol levels in medium VLDL ( 29084231) Total triglycerides levels ( 29084231) Triglyceride levels in large VLDL ( 29084231) Triglyceride levels in medium VLDL ( 29084231) Triglyceride levels in small VLDL ( 29084231) Very large VLDL particle concentration ( 29084231) Weight ( 28552196)	Alzheimer's disease (late onset) ( 30820047) Daytime sleep phenotypes ( 27126917) Hematocrit ( 27863252)
Interacting Genes		7 interacting genes: ARNT EGLN1 EGLN2 EGLN3 HIF1A HSP90AA1 VHL	25 interacting genes: ABI2 ADRB2 ATF4 EFHC2 EPAS1 EPOR FOXJ2 HIF1A HIF3A IKBKG MAPK1 MAPK7 NCAPH2 OS9 PKM PRPF19 SERTAD1 SIAH2 SRP54 SUMO1 SUMO2 SUMO3 TP53 TTC23L WDR83
Entrez ID		64344	112399
HPRD ID		17104	06972
Ensembl ID		ENSG00000124440	ENSG00000129521
Uniprot IDs		B2RBI6 H0YDZ5 M0R104 Q9Y2N7	B3KVT0 F8W1G2 Q3T1B0 Q9H6Z9
PDB IDs		4WN5
Enriched GO Terms of Interacting Partners?
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