SRSF3 and EXOSC6

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
HPRD (two hybrid)

		SRSF3	EXOSC6
Description		serine and arginine rich splicing factor 3	exosome component 6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol
	Molecular Function	RNA Binding Protein Binding Phospholipase Binding Sequence-specific MRNA Binding	RNA Binding Exoribonuclease Activity
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing MRNA Cis Splicing, Via Spliceosome Regulation Of MRNA Splicing, Via Spliceosome Cellular Response To Leukemia Inhibitory Factor	RRNA Processing RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Isotype Switching Positive Regulation Of Isotype Switching Nuclear MRNA Surveillance Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		21 interacting genes: APP CHD1 CLK1 EXOSC6 GEMIN2 HNRNPK IL7R NXF1 PCBP1 PCBP2 RBM7 RBMY1A1 SCAF11 SREK1 SRPK1 SRPK2 SRSF2 TRA2B YWHAB YWHAG YWHAQ	37 interacting genes: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 HBS1L LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MPHOSPH6 MPP6 MRPL4 MRPS18B MTREX NDUFA13 NUDT21 PSMB1 RAB3GAP2 SRSF3 TUFM UPF2 XRN1 ZFP36
Entrez ID		6428	118460
HPRD ID		04530	12107
Ensembl ID		ENSG00000112081	ENSG00000223496
Uniprot IDs		B2R6F3 P84103	Q5RKV6
PDB IDs		2I2Y 2I38	2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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