CXCL12 and MMP2

  • Number of citations of the paper that reports this interaction (PubMedID 11571304)
  • 170
  • Data Source:
  • HPRD (in vitro)

CXCL12

MMP2

Description C-X-C motif chemokine ligand 12 matrix metallopeptidase 2
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Blood protein levels ( 30072576)
  • Body mass index ( 25760438)
  • Coronary artery disease ( 26708285 24262325 26343387)
  • Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975)
  • Coronary heart disease ( 17634449 21378990)
  • Diastolic blood pressure ( 27841878)
  • Granulocyte count ( 27863252)
  • Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676)
  • Monocyte count ( 27863252)
  • Myeloid white cell count ( 27863252)
  • Myocardial infarction ( 26343387)
  • Myocardial infarction (early onset) ( 19198609)
  • Neutrophil count ( 27863252)
  • QT interval (ambient particulate matter interaction) ( 28749367)
  • Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (continuous) ( 28628665)
  • Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)
  • Schizophrenia ( 23212062)
  • Smoking initiation (ever regular vs never regular) ( 31089300)
  • Sum basophil neutrophil counts ( 27863252)
  • Sum neutrophil eosinophil counts ( 27863252)
  • White blood cell count ( 27863252)
Interacting Genes 11 interacting genes: CD4 CTSG CXCR4 DAZAP2 DPP4 ELANE FBXO7 FN1 MMP2 PF4 VCAN 37 interacting genes: A2M ACAN BACE1 BCAN CCL7 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 MTDH MTNR1A MTNR1B PZP SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4
Entrez ID 6387 4313
HPRD ID 02904 00386
Ensembl ID ENSG00000107562 ENSG00000087245
Uniprot IDs P48061 A0A024R6R4 P08253
PDB IDs 1A15 1QG7 1SDF 1VMC 2J7Z 2K01 2K03 2K04 2K05 2KEC 2KED 2KEE 2KOL 2N55 2NWG 2SDF 3GV3 3HP3 4LMQ 4UAI 1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU
Enriched GO Terms of Interacting Partners?
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