SDC4 and SGTA

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SDC4	SGTA
Description		syndecan 4	small glutamine rich tetratricopeptide repeat containing alpha
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GO Annotations	Cellular Component	Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Costamere Lysosomal Lumen Membrane Raft Extracellular Exosome	Nucleus Cytoplasm Cytosol Membrane TRC Complex Extrinsic Component Of Synaptic Vesicle Membrane
	Molecular Function	Fibronectin Binding Protein Kinase C Binding Protein Binding Identical Protein Binding Thrombospondin Receptor Activity	Protein Binding Identical Protein Binding Protein Self-association Molecular Adaptor Activity BAT3 Complex Binding
	Biological Process	Retinoid Metabolic Process Ureteric Bud Development Neural Tube Closure Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Regulation Of Fibroblast Migration Cell Migration Wound Healing Negative Regulation Of T Cell Proliferation Positive Regulation Of Protein Kinase Activity Leukocyte Migration Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Inner Ear Receptor Cell Stereocilium Organization Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Exosome Assembly	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Viral Process Ubiquitin-dependent ERAD Pathway Chaperone-mediated Protein Folding Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Chaperone-mediated Protein Folding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Psoriasis ( 20953189)
Interacting Genes		15 interacting genes: CASK CCL5 CXCR4 GIPC1 MDK PRKCA PRKCD PTEN PXN SDCBP SGTA TANK TGFB1I1 TGFB3 UBC	98 interacting genes: ADIPOQ ADRM1 AGR3 BAG6 BCL2L12 BTC C1QA C1QTNF1 C1QTNF6 C3orf52 CD79B CD99 CD99L2 CDH15 COL1A2 COL8A2 CSF1 CST1 CTSL CXCL8 EFEMP1 EFEMP2 ERP27 EVA1B F11R FERD3L FIP1L1 FKBP7 FXYD7 GABARAPL2 GAL GHR GIP GPX7 GRN GYPA HSP90AA1 HSP90AB1 HSPA13 HSPA4 HSPA8 IGL IGLC1 IRF3 IRF5 ITPRIPL1 KASH5 KRT6A KTN1 LAIR2 LAT MSMB MSTN MYDGF NAXD NME3 NR3C1 NXF1 PBXIP1 PCDHA4 PFN2 PGR PIAS1 PLAAT4 PPIB PPIC PPP1R3C PRAP1 PTN RPN1 SDC4 SERPINE1 SGCA SLPI SMAGP SOD3 SPP1 SPPL2A SRGN SYT11 SYT4 TFF3 TFRC TGFA TMEM174 TMEM31 TMPO TMUB2 TNFRSF13B TNFRSF1A TWSG1 TXNDC12 UBL4A UPK3A VIP WBP1L ZG16 ZG16B
Entrez ID		6385	6449
HPRD ID		08366	04568
Ensembl ID		ENSG00000124145	ENSG00000104969
Uniprot IDs		B4E1S6 P31431	O43765
PDB IDs		1EJP 1EJQ 1OBY 1YBO	2VYI 4CPG 4GOD 4GOE 4GOF
Enriched GO Terms of Interacting Partners?
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