S100A8 and CHGB

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		S100A8	CHGB
Description		S100 calcium binding protein A8	chromogranin B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Nucleus Cytosol Cytoskeleton Plasma Membrane Secretory Granule Lumen Intermediate Filament Cytoskeleton Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule
	Molecular Function	Calcium Ion Binding Protein Binding Microtubule Binding Zinc Ion Binding Toll-like Receptor 4 Binding Arachidonic Acid Binding RAGE Receptor Binding	Hormone Activity Protein Binding
	Biological Process	Cytokine Production Toll-like Receptor Signaling Pathway Leukocyte Migration Involved In Inflammatory Response Acute Inflammatory Response Chronic Inflammatory Response Positive Regulation Of Peptide Secretion Autophagy Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Response To Zinc Ion Astrocyte Development Peptidyl-cysteine S-nitrosylation Antimicrobial Humoral Response Positive Regulation Of Cell Growth Neutrophil Chemotaxis Sequestering Of Zinc Ion Response To Lipopolysaccharide Chemokine Production Autocrine Signaling Wound Healing Defense Response To Bacterium Neutrophil Degranulation Innate Immune Response Response To Ethanol Positive Regulation Of Inflammatory Response Defense Response To Fungus Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cytoskeleton Organization Neutrophil Aggregation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Signal Transduction Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		RHO GTPases Activate NADPH Oxidases Regulation of TLR by endogenous ligand Neutrophil degranulation Metal sequestration by antimicrobial proteins	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Calcium Zinc Copper
Diseases
GWAS		Asthma ( 31619474) Matrix metalloproteinase-8 levels ( 29212897)	Metabolite levels ( 23823483) Uterine fibroid number (single vs multiple) ( 30196971)
Interacting Genes		22 interacting genes: APP CDKN1A CEACAM3 CHGB ERG28 GDF9 IGSF21 KLC2 LRIF1 NCF2 PABPC4 PDCD11 PPIA PRMT1 PTEN RAB17 S100A9 TP53 TUBA1A TUBA4A TUBB UNC119	34 interacting genes: ACACA ANXA7 APP ATXN2 CBFB CCDC92 CDKN1A FGFR3 LRRK1 LRRK2 MARK3 MFHAS1 MGLL MOGS OGG1 PKN2 POLD1 POLR2E PRAG1 PTEN RAC2 RAP1B RCC1 RXRG S100A8 SAFB2 SLC25A6 TAZ TK1 TUBB2A TWF2 UBQLN1 UBTF YLPM1
Entrez ID		6279	1114
HPRD ID		00471	07512
Ensembl ID		ENSG00000143546	ENSG00000089199
Uniprot IDs		P05109	P05060
PDB IDs		1MR8 1XK4 4GGF 4XJK 5HLO 5HLV 5W1F 6DS2
Enriched GO Terms of Interacting Partners?
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