RARB and HR

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		RARB	HR
Description		retinoic acid receptor beta	HR lysine demethylase and nuclear receptor corepressor
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex	Chromatin Nucleus Nucleoplasm Nuclear Body
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Steroid Hormone Receptor Activity Nuclear Receptor Activity Transcription Factor Binding Drug Binding Zinc Ion Binding Nuclear Receptor Transcription Coactivator Activity Signaling Receptor Activity Protein-containing Complex Binding Retinoid X Receptor Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Activity Oxidoreductase Activity Chromatin DNA Binding Histone Demethylase Activity (H3-K9 Specific) Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Liver Development Glandular Epithelial Cell Development Outflow Tract Septum Morphogenesis Growth Plate Cartilage Development Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Multicellular Organism Development Negative Regulation Of Cell Proliferation Hormone-mediated Signaling Pathway Striatum Development Cell Differentiation Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Response To Retinoic Acid Response To Lipid Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Embryonic Digestive Tract Development Embryonic Organ Development Gland Development Ventricular Cardiac Muscle Cell Differentiation Bone Morphogenesis Epithelium Development Cellular Response To Retinoic Acid	Regulation Of Transcription, DNA-templated Histone H3-K9 Demethylation Negative Regulation Of Transcription, DNA-templated Oxidation-reduction Process
Pathways		Nuclear Receptor transcription pathway Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs		Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Arotinoid acid Tamibarotene LGD-1550
Diseases		Non-small cell lung cancer Small cell lung cancer	Atrichia with papular lesions Localized autosomal recessive hypotrichosis Marie-Unna hereditary hypotrichosis (MUHH)
GWAS		Adventurousness ( 30643258) Airflow obstruction ( 22837378) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Asthma ( 29273806) Blood urea nitrogen levels ( 31152163) BMI (adjusted for smoking behaviour) ( 28443625) BMI in smokers ( 28443625) Body mass index ( 28892062 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Calcium levels ( 25972035) Carotid intima media thickness in rheumatoid arthritis ( 30251476) Chronic obstructive pulmonary disease ( 28166215 30804561) Chronotype ( 30696823) Coffee consumption ( 31046077) Dental caries (decayed and filled deciduous teeth) ( 31533690) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Dentures ( 31235808) Dietary macronutrient intake ( 29988085) FEV1 ( 30804560) General risk tolerance (MTAG) ( 30643258) Glaucoma (primary open-angle) ( 29891935) Gout ( 22179738) Heel bone mineral density ( 30598549 28869591) Intraocular pressure ( 29785010 31959993) Low susceptibility to hepatitis C infection ( 31206233) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952) Molybdenum levels ( 26025379) Mood instability ( 31168069) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obesity (extreme) ( 19553259) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Optic disc area ( 25631615 31798171 28073927) Optic disc size ( 31809533) Optic nerve head parameters (multi-trait analysis) ( 31798171) Peak expiratory flow ( 30804560) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Pursuit maintenance gain ( 29064472) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Urinary sodium excretion ( 31409800) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Obesity-related traits ( 23251661)
Interacting Genes		20 interacting genes: ARID1A CCNH CEBPA CEBPB GATA3 HR MAP6 MEOX2 NCOA1 NCOA3 NCOR2 PNRC1 PRKD2 PSMC5 RXRA RXRB RXRG SMAD2 SMARCD3 SMARCE1	10 interacting genes: HDAC1 HDAC3 HDAC5 HMGB1 PRKCA RARA RARB TBL1X TRIM27 VDR
Entrez ID		5915	55806
HPRD ID		07183	03808
Ensembl ID		ENSG00000077092	ENSG00000168453
Uniprot IDs		F1D8S6 P10826 Q3SB16 Q5QHG3 Q86UC5	O43593
PDB IDs		1HRA 1XAP 4DM6 4DM8 4JYG 4JYH 4JYI 5UAN 6SSQ
Enriched GO Terms of Interacting Partners?
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