RPS6KA1 and MAGI2

Number of citations of the paper that reports this interaction (PubMedID 30726710)
1

Data Source:
BioGRID (unspecified method)

		RPS6KA1	MAGI2
Description		ribosomal protein S6 kinase A1	membrane associated guanylate kinase, WW and PDZ domain containing 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm Late Endosome Plasma Membrane Cell-cell Junction Bicellular Tight Junction Postsynaptic Density Dendrite Protein-containing Complex Slit Diaphragm Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Protein Binding Phosphatase Binding Receptor Signaling Complex Scaffold Activity Beta-1 Adrenergic Receptor Binding SMAD Binding Type II Activin Receptor Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Cell Cycle Signal Transduction Positive Regulation Of Cell Growth Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Proliferation Positive Regulation Of Hepatic Stellate Cell Activation	Positive Regulation Of Receptor Internalization Planar Cell Polarity Pathway Involved In Axis Elongation Signal Transduction Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Positive Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Activin Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Receptor Clustering Protein Heterooligomerization Negative Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Mitotic Cell Cycle Arrest Glomerular Visceral Epithelial Cell Development Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Synaptic Vesicle Clustering
Pathways		ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK	Nephrin family interactions
Drugs		Purvalanol A
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Glucose homeostasis traits ( 25524916) Mean corpuscular volume ( 27863252) Rosacea symptom severity ( 29771307) Triglyceride levels ( 30108155)	Acute lymphoblastic leukemia (childhood) ( 23007406) Adverse response to drug ( 30420678) Airway wall thickness ( 25517131) Bitter beverage consumption ( 31046077) Body mass index ( 28892062 25673413) Bronchopulmonary dysplasia ( 23897914) Chronotype ( 30696823) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) General risk tolerance (MTAG) ( 30643258) Hippocampal atrophy ( 19668339) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol levels x short total sleep time interaction (1df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lead levels in blood ( 25820613) Mammographic density (dense area) ( 25342443) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Pursuit maintenance gain ( 29064472) Response to anti-depressant treatment in major depressive disorder ( 22041458) Schizophrenia ( 28991256 30285260) Serum folate levels ( 29953918) Visceral fat ( 30942860)
Interacting Genes		86 interacting genes: ARHGEF11 ARHGEF12 ATXN3 BAD CARHSP1 CCT4 CDKN1B CEBPB CFL1 CREB1 CREBBP DDAH2 DEPTOR DLC1 DLG4 EEF1D EEF2K ERBIN ESR1 ETV1 FGFR1 FOS GBP2 GMFB GOPC GORASP1 GORASP2 GRB2 GRID2IP GSK3B HTRA1 L1CAM LIMK2 LNX1 MAGI1 MAGI2 MAGI3 MAPK1 MAPK3 MAPT MAST1 MAST2 METTL1 MITF MPP1 MTOR MXD1 NFKBIA NR4A1 NR4A2 NR4A3 PARD3B PDCD4 PDPK1 PDZD7 PDZK1 PDZRN3 PDZRN4 PHAX POLDIP3 PPM1G PPP1R3A PPP1R9A PTPN3 RPTOR SHANK3 SHROOM2 SLC9A3R2 SNTA1 SNTB1 SNTG2 SNX27 SRF SRSF5 SYK SYNJ2BP TAMALIN TOB2 TP53 TSC2 TTK UBE2T VCP WHRN YBX1 YWHAB	17 interacting genes: ACVR2A ADGRB1 ADRB1 ARRDC3 ATN1 CRHR1 CTNNB1 CTNND2 DLL1 DSCAML1 GRID2 PLXNB3 PTEN RAPGEF2 RPS6KA1 SMAD3 TGFA
Entrez ID		6195	9863
HPRD ID		03402	16212
Ensembl ID		ENSG00000117676	ENSG00000187391
Uniprot IDs		Q15418	B7Z4H4 Q86UL8
PDB IDs		2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P 4NIF 5CSF 5CSI 5CSJ 5CSN 5N7D 5N7F 5N7G 5V61 5V62	1UEP 1UEQ 1UEW 1UJV 1WFV
Enriched GO Terms of Interacting Partners?
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