RPS2 and PRMT3

Number of citations of the paper that reports this interaction (PubMedID 26186194)
367

Data Source:
BioGRID (enzymatic study, affinity chromatography technology, affinity chromatography technology)

		RPS2	PRMT3
Description		ribosomal protein S2	protein arginine methyltransferase 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Focal Adhesion Membrane Cytosolic Small Ribosomal Subunit Extracellular Exosome	Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Binding MRNA Binding Structural Constituent Of Ribosome Protein Binding Fibroblast Growth Factor Binding Enzyme Binding Cadherin Binding	Nucleic Acid Binding Protein Binding Methyltransferase Activity Protein-arginine N-methyltransferase Activity Ribosome Binding Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RRNA Processing Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription Positive Regulation Of Ubiquitin-protein Transferase Activity	Protein Methylation Negative Regulation Of Protein Ubiquitination Peptidyl-arginine N-methylation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis RMTs methylate histone arginines rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Protein methylation Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	RMTs methylate histone arginines Protein methylation
Drugs		Copper	S-adenosyl-L-homocysteine
Diseases
GWAS		Atrial fibrillation ( 29892015)	Carotid intima media thickness (maximum) ( 31801372) Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906) Pursuit maintenance gain ( 29064472) Response to inhaled glucocorticoid treatment in asthma (change in FEV1) ( 25601762)
Interacting Genes		19 interacting genes: ANXA2 ANXA7 CDKN1A DNM2 FBXO7 FGF1 FGF3 GABARAPL2 GADD45A GRB7 GSK3B MPP3 PRMT3 PTEN SMN1 SOX5 TK1 TRAF6 YWHAG	8 interacting genes: FBL HNRNPA1 PABPN1 PPARD RASSF2 RPS2 STAT1 TSC22D2
Entrez ID		6187	10196
HPRD ID		04690	11934
Ensembl ID		ENSG00000140988	ENSG00000185238
Uniprot IDs		P15880	O60678 Q8WUV3
PDB IDs		4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6G18 6G4S 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP	2FYT 3SMQ 4HSG 4QQN 4RYL
Enriched GO Terms of Interacting Partners?
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