PRMT3 and RPS2

Number of citations of the paper that reports this interaction (PubMedID 26186194)
367

Data Source:
BioGRID (enzymatic study, affinity chromatography technology, affinity chromatography technology)

		PRMT3	RPS2
Description		protein arginine methyltransferase 3	ribosomal protein S2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Cytosol Focal Adhesion Membrane Cytosolic Small Ribosomal Subunit Extracellular Exosome
	Molecular Function	Nucleic Acid Binding Protein Binding Methyltransferase Activity Protein-arginine N-methyltransferase Activity Ribosome Binding Metal Ion Binding	RNA Binding MRNA Binding Structural Constituent Of Ribosome Protein Binding Fibroblast Growth Factor Binding Enzyme Binding Cadherin Binding
	Biological Process	Protein Methylation Negative Regulation Of Protein Ubiquitination Peptidyl-arginine N-methylation	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RRNA Processing Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription Positive Regulation Of Ubiquitin-protein Transferase Activity
Pathways		RMTs methylate histone arginines Protein methylation	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis RMTs methylate histone arginines rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Protein methylation Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		S-adenosyl-L-homocysteine	Copper
Diseases
GWAS		Carotid intima media thickness (maximum) ( 31801372) Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906) Pursuit maintenance gain ( 29064472) Response to inhaled glucocorticoid treatment in asthma (change in FEV1) ( 25601762)	Atrial fibrillation ( 29892015)
Interacting Genes		8 interacting genes: FBL HNRNPA1 PABPN1 PPARD RASSF2 RPS2 STAT1 TSC22D2	19 interacting genes: ANXA2 ANXA7 CDKN1A DNM2 FBXO7 FGF1 FGF3 GABARAPL2 GADD45A GRB7 GSK3B MPP3 PRMT3 PTEN SMN1 SOX5 TK1 TRAF6 YWHAG
Entrez ID		10196	6187
HPRD ID		11934	04690
Ensembl ID		ENSG00000185238	ENSG00000140988
Uniprot IDs		O60678 Q8WUV3	P15880
PDB IDs		2FYT 3SMQ 4HSG 4QQN 4RYL	4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6G18 6G4S 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
Enriched GO Terms of Interacting Partners?
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