RING1 and E2F6

Number of citations of the paper that reports this interaction (PubMedID 11171983)
91

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		RING1	E2F6
Description		ring finger protein 1	E2F transcription factor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Sex Chromatin Nucleus Nucleoplasm Cytosol Nuclear Speck PcG Protein Complex PRC1 Complex	Nuclear Chromatin Nucleus Nucleoplasm MLL1 Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	Chromatin Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activator Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity
	Biological Process	Anterior/posterior Pattern Specification Histone H2A Monoubiquitination Negative Regulation Of Transcription, DNA-templated Camera-type Eye Morphogenesis Regulation Of Catalytic Activity Negative Regulation Of G0 To G1 Transition	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Negative Regulation Of G0 To G1 Transition
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	G1/S-Specific Transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Wegener's granulomatosis ( 23740775)	Diisocyanate-induced asthma ( 25918132) Sudden cardiac arrest ( 21658281)
Interacting Genes		24 interacting genes: APP BMI1 CBX4 CBX7 CBX8 E2F6 ELAC2 ERG FBXO38 FHL1 H3-4 PHC1 PIK3R3 RB1 RNF2 RYBP TP53 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2E3 UBE2K	28 interacting genes: APP ARAF BMI1 BRDT CENPU DNMT1 DNMT3L DNTTIP1 E2F1 EPC1 EZH1 EZH2 HMG20B INO80B KRTAP10-7 MDN1 NFYA PCGF6 PIK3R3 RING1 RYBP SMARCA4 TFDP1 TFDP2 ZBTB17 ZBTB32 ZFPM2 ZMYND11
Entrez ID		6015	1876
HPRD ID		03624	04251
Ensembl ID		ENSG00000204227	ENSG00000169016
Uniprot IDs		A0A1U9X8F2 Q06587	A0A0S2Z3K8 O75461 Q53YM3 Q6Q9Z5
PDB IDs
Enriched GO Terms of Interacting Partners?
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