RHEB and RNF152

Number of citations of the paper that reports this interaction (PubMedID 30514904)
7

Data Source:
BioGRID (pull down)

		RHEB	RNF152
Description		Ras homolog, mTORC1 binding	ring finger protein 152
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Spliceosomal Complex Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Postsynaptic Density Membrane Extracellular Exosome	Lysosome Lysosomal Membrane Integral Component Of Organelle Membrane
	Molecular Function	Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding	Ubiquitin-protein Transferase Activity Small GTPase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cell Cycle Arrest Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Positive Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Cold-induced Thermogenesis Regulation Of Type B Pancreatic Cell Development	Apoptotic Process Positive Regulation Of Autophagy Protein Ubiquitination Cellular Response To Amino Acid Starvation Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Negative Regulation Of TORC1 Signaling
Pathways		Macroautophagy mTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	E3 ubiquitin ligases ubiquitinate target proteins
Drugs		Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Metabolite levels ( 23823483)	Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate (creatinine) ( 28452372 26831199)
Interacting Genes		26 interacting genes: A2M APOE ARIH2 ATM ATR BNIP3 BNIP3L BRAF CREB3 ECSIT FKBP8 HTT MTOR NCAM1 PDE6D PLD1 PSEN1 PSEN2 RABAC1 RAF1 RNF152 RPS6KB1 RPTOR TSC1 TSC2 USP4	6 interacting genes: CROCC RHEB RRAGA UBE2E1 UBE2N UBE2W
Entrez ID		6009	220441
HPRD ID		03188	11514
Ensembl ID		ENSG00000106615	ENSG00000176641
Uniprot IDs		A0A090N900 Q15382	Q8N8N0
PDB IDs		1XTQ 1XTR 1XTS 3SEA 3T5G 5YXH 6BCU 6BSX 6BT0
Enriched GO Terms of Interacting Partners?
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