RGS12 and GRM2

Number of citations of the paper that reports this interaction (PubMedID 9651375)
49

Data Source:
HPRD (in vitro)

		RGS12	GRM2
Description		regulator of G protein signaling 12	glutamate metabotropic receptor 2
Image
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Nuclear Matrix Cell Junction Dendrite Synapse	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Axon Dendrite Presynaptic Membrane Integral Component Of Postsynaptic Membrane
	Molecular Function	GTPase Activity GTPase Activator Activity GTPase Regulator Activity	Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Glutamate Secretion Regulation Of Synaptic Transmission, Glutamatergic Glutamate Homeostasis
Pathways		G alpha (i) signalling events G alpha (i) signalling events	G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs			LY2140023
Diseases
GWAS		Blood protein levels ( 28240269) Coronary artery disease ( 29212778) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 29403010) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Platelet count ( 29403010) Serum albumin level ( 29403010) Total cholesterol levels ( 29403010) Tuberculosis ( 29036319) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		16 interacting genes: ARAF CACNA1B CXCR2 EEF1A1 GNAI1 GNAI2 GNAI3 GRM2 GRM5 HRAS MAP2K2 MTNR1A NPY2R PLCB1 PLCB3 YWHAG	9 interacting genes: GNA15 GNAQ GRIP1 LMNA NAALADL2 RGS12 SDCBP TAMALIN UBQLN1
Entrez ID		6002	2912
HPRD ID		03943	04977
Ensembl ID		ENSG00000159788	ENSG00000164082
Uniprot IDs		O14924	Q14416
PDB IDs		2EBZ 2KV8	4XAQ 4XAS 5CNI 5CNJ 5KZN 5KZQ
Enriched GO Terms of Interacting Partners?
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