RGS4 and PTAFR

Number of citations of the paper that reports this interaction (PubMedID 11297424)
2

Data Source:
HPRD (in vitro)

		RGS4	PTAFR
Description		regulator of G protein signaling 4	platelet activating factor receptor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Protein-containing Complex	Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Secretory Granule Membrane Tertiary Granule Membrane
	Molecular Function	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding	Lipopolysaccharide Binding Lipopolysaccharide Receptor Activity G Protein-coupled Receptor Activity Platelet Activating Factor Receptor Activity Protein Binding Phospholipid Binding G Protein-coupled Purinergic Nucleotide Receptor Activity Mitogen-activated Protein Kinase Binding
	Biological Process	Inactivation Of MAPK Activity Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Brain Development Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Heart Rate Response To Cocaine Response To Morphine Positive Regulation Of GTPase Activity Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transport Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Actin Filament Organization Negative Regulation Of Glycine Import Across Plasma Membrane Negative Regulation Of Potassium Ion Transmembrane Transport Dorsal Root Ganglion Development Positive Regulation Of Excitatory Postsynaptic Potential	Cytokine Production Regulation Of Transcription By RNA Polymerase II Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Parturition Response To Symbiotic Bacterium Positive Regulation Of Phospholipase C Activity Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Inositol Trisphosphate Biosynthetic Process G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Neutrophil Degranulation Positive Regulation Of Neutrophil Degranulation Transcytosis Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Translation Negative Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Phosphatidylinositol-mediated Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Inositol Phosphate Biosynthetic Process Cellular Response To Gravity Cellular Response To CAMP Cellular Response To Fatty Acid Response To Dexamethasone Positive Regulation Of Blood Vessel Diameter Positive Regulation Of Voltage-gated Chloride Channel Activity Positive Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Sensory Perception Of Pain Positive Regulation Of Transcytosis Positive Regulation Of Maternal Process Involved In Parturition Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Cellular Response To 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine
Pathways		G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events	Class A/1 (Rhodopsin-like receptors) G alpha (q) signalling events Interleukin-10 signaling Neutrophil degranulation Interferon gamma signaling
Drugs			Platelet Activating Factor Etizolam Rupatadine
Diseases
GWAS		Response to fenofibrate (triglyceride levels) ( 27002377) Response to mTOR inhibitor (rapamycin) ( 24009623)	Blond vs. brown/black hair color ( 30531825)
Interacting Genes		13 interacting genes: CALM1 COPB1 COPB2 EGFR ERBB3 GABBR1 GNAI1 GNAI2 GNAO1 GNAQ KRIT1 PLCB1 PTAFR	8 interacting genes: ARR3 ARRB2 CALM1 GORAB GTPBP3 RGS4 SPATA24 TYK2
Entrez ID		5999	5724
HPRD ID		03947	01422
Ensembl ID		ENSG00000117152	ENSG00000169403
Uniprot IDs		A0A024R909 P49798	A8K7N8 P25105
PDB IDs			2B0X
Enriched GO Terms of Interacting Partners?
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