RBL2 and LIN52

Number of citations of the paper that reports this interaction (PubMedID 25917549)
31

Data Source:
BioGRID (pull down)

		RBL2	LIN52
Description		RB transcriptional corepressor like 2	lin-52 DREAM MuvB core complex component
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GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Extracellular Exosome	Nucleoplasm DRM Complex
	Molecular Function	RNA Polymerase II Regulatory Region DNA Binding RNA Polymerase II Activating Transcription Factor Binding Protein Binding Promoter-specific Chromatin Binding
	Biological Process	Chromatin Organization Regulation Of Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Regulation Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Cell Differentiation Regulation Of Lipid Kinase Activity Regulation Of Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Transcription, DNA-templated Regulation Of Cell Cycle
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry FOXO-mediated transcription of cell cycle genes	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases
GWAS		Body fat mass ( 28552196) General cognitive ability ( 29844566) Height ( 28552196) Intelligence (MTAG) ( 29326435) Metabolite levels ( 23823483)	Blood protein levels ( 28240269) Chronotype ( 30696823) Macular thickness ( 30535121) Waist-hip ratio ( 28552196)
Interacting Genes		44 interacting genes: BRCA1 BRF1 BRF2 CCNA1 CCNA2 CCND1 CCND3 CCNE1 CDK2 CDK4 CDK6 CREG1 DCTN1 DGKZ E2F4 E2F5 EZH2 GRAMD4 HBP1 HDAC1 ID2 KMT5C LBX1 LDHC LIN52 MCM7 MNDA PCBD1 PHB PPP2CA RAF1 RBBP8 RBBP9 RINT1 SKP2 SMARCA4 SNW1 SUV39H1 TAF1 TOP1 TP53BP1 UBTF USP4 XBP1	5 interacting genes: DYRK1A MYBL2 NEK9 RBBP4 RBL2
Entrez ID		5934	91750
HPRD ID		01576	18708
Ensembl ID		ENSG00000103479	ENSG00000205659
Uniprot IDs		Q08999	B3KN83 Q52LA3
PDB IDs		4XI9 5C1D	4YOO 6C48
Enriched GO Terms of Interacting Partners?
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