RBL2 and CCND1

Number of citations of the paper that reports this interaction (PubMedID 16600870)
16

Data Source:
HPRD (two hybrid)

		RBL2	CCND1
Description		RB transcriptional corepressor like 2	cyclin D1
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GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Extracellular Exosome	Cyclin-dependent Protein Kinase Holoenzyme Complex Intracellular Nucleus Nucleoplasm Cytoplasm Cytosol Bicellular Tight Junction Transcriptional Repressor Complex Nuclear Membrane
	Molecular Function	RNA Polymerase II Regulatory Region DNA Binding RNA Polymerase II Activating Transcription Factor Binding Protein Binding Promoter-specific Chromatin Binding	Transcription Corepressor Activity Protein Kinase Activity Protein Binding Transcription Factor Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding Protein-containing Complex Binding Proline-rich Region Binding
	Biological Process	Chromatin Organization Regulation Of Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Regulation Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Cell Differentiation Regulation Of Lipid Kinase Activity Regulation Of Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Re-entry Into Mitotic Cell Cycle Positive Regulation Of Protein Phosphorylation Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Cellular Response To DNA Damage Stimulus Lactation Response To Iron Ion Response To X-ray Response To Organonitrogen Compound Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Wnt Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Mitotic G1 DNA Damage Checkpoint Response To Magnesium Ion Response To Estradiol Response To Vitamin E Leydig Cell Differentiation Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Response To Drug Response To Estrogen Response To Leptin Mitotic Cell Cycle Phase Transition Fat Cell Differentiation Response To Ethanol Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle Cell Division Response To Corticosterone Response To Calcium Ion Mammary Gland Alveolus Development Response To UV-A Negative Regulation Of Cell Cycle Arrest Liver Regeneration Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry FOXO-mediated transcription of cell cycle genes	SCF(Skp2)-mediated degradation of p27/p21 Pre-NOTCH Transcription and Translation RMTs methylate histone arginines Interleukin-4 and Interleukin-13 signaling Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional Regulation by VENTX Transcriptional regulation by RUNX2 Regulation of RUNX1 Expression and Activity RUNX3 regulates WNT signaling RUNX3 regulates p14-ARF Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs			Arsenic trioxide
Diseases			Hairy-cell leukemia von Hippel-Lindau syndrome Esophageal cancer Oral cancer Multiple myeloma Laryngeal cancer Breast cancer
GWAS		Body fat mass ( 28552196) General cognitive ability ( 29844566) Height ( 28552196) Intelligence (MTAG) ( 29326435) Metabolite levels ( 23823483)	Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Body fat distribution (arm fat ratio) ( 30664634) Breast cancer ( 29059683 20453838) Breast cancer (early onset) ( 24493630) Breast size ( 22747683 27182965) Craniofacial microsomia ( 26853712) Cutaneous malignant melanoma ( 26237428) Diastolic blood pressure ( 27841878) Height ( 25429064) Hip circumference ( 25673412) Idiopathic dilated cardiomyopathy ( 29495422) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Melanoma ( 28212542) Multiple myeloma (IgH translocation) ( 23502783) Nevus count or cutaneous melanoma ( 30429480) Offspring birth weight ( 31043758) Total body bone mineral density ( 29304378) Type 2 diabetes ( 30297969 30718926)
Interacting Genes		44 interacting genes: BRCA1 BRF1 BRF2 CCNA1 CCNA2 CCND1 CCND3 CCNE1 CDK2 CDK4 CDK6 CREG1 DCTN1 DGKZ E2F4 E2F5 EZH2 GRAMD4 HBP1 HDAC1 ID2 KMT5C LBX1 LDHC LIN52 MCM7 MNDA PCBD1 PHB PPP2CA RAF1 RBBP8 RBBP9 RINT1 SKP2 SMARCA4 SNW1 SUV39H1 TAF1 TOP1 TP53BP1 UBTF USP4 XBP1	70 interacting genes: AKAP8 AR ARID4A ATF2 BCAS3 BRCA1 BRCA2 BRINP1 BTRC CALM1 CAMK1 CCNDBP1 CDH13 CDK4 CDK6 CDKN1A CDKN1B CRYAB CTNNB1 CUL2 CUL3 DMTF1 EP300 ESR1 FBXO31 FBXO4 FOS GSK3B HDAC3 HERC5 IFI27 INSM1 JUN JUND KAT2B KLK7 KLK9 LPL MAPK11 MCM10 MCM7 MYBL2 NCOA1 NCOA3 NPDC1 ORC4 PCNA POLR1B PRKACA PRKN RABEP1 RAD51 RANBP9 RB1 RBL1 RBL2 RBX1 RFC1 RUNX1 SP1 STAT3 TAF1 THRA THRB TP73 TSC2 UBTF UHRF2 USP2 XPO1
Entrez ID		5934	595
HPRD ID		01576	01346
Ensembl ID		ENSG00000103479	ENSG00000110092
Uniprot IDs		Q08999	P24385 Q6FI00
PDB IDs		4XI9 5C1D	2W96 2W99 2W9F 2W9Z 5VZU
Enriched GO Terms of Interacting Partners?
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