RBL1 and KDM5A

Number of citations of the paper that reports this interaction (PubMedID 7935440)
14

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		RBL1	KDM5A
Description		RB transcriptional corepressor like 1	lysine demethylase 5A
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GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Factor Complex	Nucleus Nucleoplasm Nucleolus Protein-DNA Complex Histone Methyltransferase Complex
	Molecular Function	RNA Polymerase II Regulatory Region DNA Binding RNA Polymerase II Activating Transcription Factor Binding Protein Binding Transcription Factor Binding Promoter-specific Chromatin Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Histone Demethylase Activity Histone Demethylase Activity (H3-trimethyl-K4 Specific) Histone Demethylase Activity (H3-dimethyl-K4 Specific) Methylated Histone Binding Histone Binding Transcription Regulatory Region DNA Binding Dioxygenase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Cell Cycle Regulation Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Viral Process Cell Differentiation Regulation Of Lipid Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cellular Senescence	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Spermatogenesis Male Gonad Development Circadian Regulation Of Gene Expression Histone H3-K4 Demethylation Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Positive Regulation Of Transcription, DNA-templated Regulation Of DNA-binding Transcription Factor Activity Oxidation-reduction Process Negative Regulation Of Histone Deacetylase Activity
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest G1/S-Specific Transcription Cyclin D associated events in G1	HDMs demethylate histones
Drugs
Diseases
GWAS		Height ( 25429064) Red cell distribution width ( 28957414)	Body mass index ( 26426971) Pulse pressure ( 27841878)
Interacting Genes		54 interacting genes: AOX1 BEGAIN BRCA1 BRF1 CCNA1 CCNA2 CCND1 CCNE1 CDK2 CDK4 CDK6 CEBPA CREG1 DGKZ DHX30 DYRK1A E2F1 E2F4 E2F5 EPHA2 FN1 GOLGA2 HDAC1 ID2 IRF3 KDM5A KMT5C LAMB2 MAPK6 MCM7 MYBL2 MYC NR2E3 NR4A1 NUCB1 PHB PLSCR1 PPP2R3A RBBP8 RBBP9 RINT1 SMAD2 SMAD3 SMAD4 SMARCA4 SNRPD3 SNW1 SP1 SUV39H1 TAF1 TOP1 TP53BP1 TSC22D2 USP4	11 interacting genes: ESR1 H3-4 H3C15 LMO2 NR3C1 PKP2 RARA RB1 RBL1 TBP VDR
Entrez ID		5933	5927
HPRD ID		00312	08915
Ensembl ID		ENSG00000080839	ENSG00000073614
Uniprot IDs		P28749	P29375
PDB IDs		1H28 4YOO 4YOS 4YOZ 5TUV	2JXJ 2KGG 2KGI 3GL6 5C11 5CEH 5E6H 5ISL 5IVB 5IVC 5IVE 5IVF 5IVJ 5IVV 5IVY 5IW0 5IWF 5K4L 5V9P 5V9T 6BGU 6BGV 6BGW 6BGX 6BGY 6BGZ 6BH0 6BH1 6BH2 6BH3 6BH4 6BH5 6DQ4 6DQ5 6DQ6 6DQ7 6DQ8 6DQ9 6DQA 6DQB 6DQC 6DQD 6DQE 6DQF
Enriched GO Terms of Interacting Partners?
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