KDM5A and PKP2

		KDM5A	PKP2
Description		lysine demethylase 5A	plakophilin 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Protein-DNA Complex Histone Methyltransferase Complex	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Intercalated Disc Integral Component Of Membrane Cell Junction Desmosome Messenger Ribonucleoprotein Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Histone Demethylase Activity Histone Demethylase Activity (H3-trimethyl-K4 Specific) Histone Demethylase Activity (H3-dimethyl-K4 Specific) Methylated Histone Binding Histone Binding Transcription Regulatory Region DNA Binding Dioxygenase Activity	Protein Kinase C Binding Protein Binding Sodium Channel Regulator Activity Intermediate Filament Binding Ion Channel Binding Alpha-catenin Binding Cadherin Binding Molecular Adaptor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Spermatogenesis Male Gonad Development Circadian Regulation Of Gene Expression Histone H3-K4 Demethylation Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Positive Regulation Of Transcription, DNA-templated Regulation Of DNA-binding Transcription Factor Activity Oxidation-reduction Process Negative Regulation Of Histone Deacetylase Activity	Desmosome Assembly Desmosome Organization Cell-cell Junction Assembly Heart Development Positive Regulation Of Sodium Ion Transport Keratinization Intermediate Filament Bundle Assembly Maintenance Of Animal Organ Identity Ventricular Cardiac Muscle Tissue Morphogenesis Cornification Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Cell-cell Signaling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Involved In Cardiac Conduction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways		HDMs demethylate histones	Keratinization Formation of the cornified envelope
Drugs
Diseases			Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Body mass index ( 26426971) Pulse pressure ( 27841878)	Atrial fibrillation ( 30061737 29892015) Blood protein levels ( 30072576) Body mass index (change over time) in lung cancer ( 28044437) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Parkinson's disease ( 27182965) Periodontal disease related phenotype (PCT5) ( 26962152) Prevalent atrial fibrillation ( 28416818)
Interacting Genes		11 interacting genes: ESR1 H3-4 H3C15 LMO2 NR3C1 PKP2 RARA RB1 RBL1 TBP VDR	26 interacting genes: AKAP9 CASK CTNNB1 DDX11 DMRTB1 DSC1 DSC2 DSG1 DSG2 DSP GTF2IRD1 HSPB2 ITPR2 JUP KDM5A KLC4 KRT18 KRT5 MARK3 MTUS2 NDEL1 POLR3A RBM5 SINHCAF SMAD9 YWHAG
Entrez ID		5927	5318
HPRD ID		08915	04177
Ensembl ID		ENSG00000073614	ENSG00000057294
Uniprot IDs		P29375	Q99959
PDB IDs		2JXJ 2KGG 2KGI 3GL6 5C11 5CEH 5E6H 5ISL 5IVB 5IVC 5IVE 5IVF 5IVJ 5IVV 5IVY 5IW0 5IWF 5K4L 5V9P 5V9T 6BGU 6BGV 6BGW 6BGX 6BGY 6BGZ 6BH0 6BH1 6BH2 6BH3 6BH4 6BH5 6DQ4 6DQ5 6DQ6 6DQ7 6DQ8 6DQ9 6DQA 6DQB 6DQC 6DQD 6DQE 6DQF	3TT9
Enriched GO Terms of Interacting Partners?
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