PKP2 and DSC2

Number of citations of the paper that reports this interaction (PubMedID 11790773)
73

Data Source:
HPRD (two hybrid)

		PKP2	DSC2
Description		plakophilin 2	desmocollin 2
Image
GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Intercalated Disc Integral Component Of Membrane Cell Junction Desmosome Messenger Ribonucleoprotein Complex	Cornified Envelope Plasma Membrane Cell-cell Junction Adherens Junction Intercalated Disc Integral Component Of Membrane Desmosome Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Protein Kinase C Binding Protein Binding Sodium Channel Regulator Activity Intermediate Filament Binding Ion Channel Binding Alpha-catenin Binding Cadherin Binding Molecular Adaptor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication	Calcium Ion Binding Protein Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process	Desmosome Assembly Desmosome Organization Cell-cell Junction Assembly Heart Development Positive Regulation Of Sodium Ion Transport Keratinization Intermediate Filament Bundle Assembly Maintenance Of Animal Organ Identity Ventricular Cardiac Muscle Tissue Morphogenesis Cornification Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Cell-cell Signaling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Involved In Cardiac Conduction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cellular Response To Starvation Keratinization Cornification Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways		Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope
Drugs
Diseases		Arrhythmogenic right ventricular cardiomyopathy (ARVC)	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Atrial fibrillation ( 30061737 29892015) Blood protein levels ( 30072576) Body mass index (change over time) in lung cancer ( 28044437) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Parkinson's disease ( 27182965) Periodontal disease related phenotype (PCT5) ( 26962152) Prevalent atrial fibrillation ( 28416818)	Blood protein levels ( 30072576 29875488) Bronchopulmonary dysplasia ( 23897914) Metabolite levels ( 23823483)
Interacting Genes		26 interacting genes: AKAP9 CASK CTNNB1 DDX11 DMRTB1 DSC1 DSC2 DSG1 DSG2 DSP GTF2IRD1 HSPB2 ITPR2 JUP KDM5A KLC4 KRT18 KRT5 MARK3 MTUS2 NDEL1 POLR3A RBM5 SINHCAF SMAD9 YWHAG	6 interacting genes: CLK1 DSG1 DSG2 JUP PKP2 PKP3
Entrez ID		5318	1824
HPRD ID		04177	00512
Ensembl ID		ENSG00000057294	ENSG00000134755
Uniprot IDs		Q99959	A0A3B3ISU0 Q02487
PDB IDs		3TT9	5ERP 5J5J
Enriched GO Terms of Interacting Partners?
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