RAP1A and RASGRP4

Number of citations of the paper that reports this interaction (PubMedID 11880369)
36

Data Source:
HPRD (in vitro)

		RAP1A	RASGRP4
Description		RAP1A, member of RAS oncogene family	RAS guanyl releasing protein 4
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GO Annotations	Cellular Component	Cytoplasm Early Endosome Late Endosome Cytosol Plasma Membrane Cell Junction Guanyl-nucleotide Exchange Factor Complex Specific Granule Membrane Neuron Projection Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse	Nucleoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Rap Guanyl-nucleotide Exchange Factor Activity GDP Binding Protein-containing Complex Binding	Ras Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Diacylglycerol Binding GTP-dependent Protein Binding
	Biological Process	Response To Carbohydrate Positive Regulation Of Neuron Projection Development Microvillus Assembly Rap Protein Signal Transduction Negative Regulation Of Collagen Biosynthetic Process Cellular Response To Drug Nerve Growth Factor Signaling Pathway Neutrophil Degranulation Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Glucose Import Regulation Of Insulin Secretion Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Protein Localization To Plasma Membrane Response To Antineoplastic Agent Liver Regeneration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Cell Junction Assembly Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Vasculogenesis	MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity Small GTPase Mediated Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Proliferation Response To Extracellular Stimulus Myeloid Cell Differentiation Positive Regulation Of Ras Protein Signal Transduction
Pathways		Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation ARMS-mediated activation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Signaling downstream of RAS mutants	FCERI mediated NF-kB activation RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 30500874) High altitude adaptation ( 28373541) Osteoporosis-related phenotypes ( 20548944)	Diisocyanate-induced asthma ( 25918132) Eosinophil counts ( 27863252) Eosinophil percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		43 interacting genes: AFDN APBB1IP ARHGEF1 BIN1 BMX BRAF ELOA FADD FAF1 FAS GABARAPL2 GANAB HDAC1 HSPA1A HSPA4 KRIT1 MTNR1A NTRK1 PDE6D PPP2R1A PRKACA RABAC1 RAF1 RALGDS RAP1GAP RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASA1 RASA3 RASGRP2 RASGRP4 RASIP1 RGL4 RGS14 RUNDC3A SMARCA2 SMARCA4 TNFRSF10C	2 interacting genes: HRAS RAP1A
Entrez ID		5906	115727
HPRD ID		01545	09540
Ensembl ID		ENSG00000116473	ENSG00000171777
Uniprot IDs		A8KAH9 P62834	Q8TDF6
PDB IDs		1C1Y 1GUA 3KUC 4KVG	6AXG
Enriched GO Terms of Interacting Partners?
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