RAB5B and TFRC

Number of citations of the paper that reports this interaction (PubMedID 7789520)
62

Data Source:
HPRD (in vivo)

		RAB5B	TFRC
Description		RAB5B, member RAS oncogene family	transferrin receptor
Image
GO Annotations	Cellular Component	Intracellular Endosome Early Endosome Plasma Membrane Endomembrane System Membrane Endocytic Vesicle Secretory Granule Membrane Early Endosome Membrane Melanosome Intracellular Membrane-bounded Organelle Extracellular Exosome Anchored Component Of Synaptic Vesicle Membrane	Extracellular Region Extracellular Space Cell Endosome Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Melanosome Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Blood Microparticle Extracellular Vesicle HFE-transferrin Receptor Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding GTP-dependent Protein Binding	Virus Receptor Activity RNA Binding Double-stranded RNA Binding Transferrin Receptor Activity Protein Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding
	Biological Process	Intracellular Protein Transport Endocytosis Endosome Organization Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Neutrophil Degranulation Plasma Membrane To Endosome Transport	Regulation Of Cell Growth Positive Regulation Of Protein Phosphorylation Iron Ion Transport Cellular Iron Ion Homeostasis Positive Regulation Of Gene Expression Osteoclast Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Complex Assembly Receptor Internalization Positive Regulation Of Peptidyl-serine Phosphorylation Transferrin Transport Cellular Response To Drug Positive Regulation Of T Cell Proliferation Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Bone Resorption Positive Regulation Of Isotype Switching Viral Entry Into Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Membrane Organization Positive Regulation Of Protein Localization To Nucleus Cellular Response To Leukemia Inhibitory Factor
Pathways		Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Transferrin endocytosis and recycling
Drugs			Iron
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Anorexia nervosa ( 28494655) Asthma ( 30929738 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Cognitive function ( 25644384) FEV1 ( 30804560) Gastroesophageal reflux disease ( 31527586) Lung function (FEV1) ( 30061609) Lung function (FEV1/FVC) ( 30804560) Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease) ( 31015401) Polycystic ovary syndrome ( 22885925 30566500) Sum eosinophil basophil counts ( 27863252) Type 1 diabetes ( 18198356) Vitiligo ( 22951725)	Asthma ( 30929738) Asthma (adult onset) ( 30929738) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 25352340) Mean corpuscular hemoglobin ( 28453575 20139978 27863252 19862010) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 28453575 20139978 27863252 19862010) Neurofibrillary tangles ( 31497858) Pancreatic cancer ( 22158540) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 28957414) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		17 interacting genes: APOA5 CDK1 CHM EEA1 GLP1R PIK3CB PRIM1 RABAC1 REEP5 RIN1 RIN2 RIN3 SGSM3 SUN2 TBC1D15 TBC1D17 TFRC	12 interacting genes: ACAP1 B4GALT1 CD247 CD4 GABARAP HFE LMNA RAB5B RAB8A RANBP9 SGTA TF
Entrez ID		5869	7037
HPRD ID		01544	01812
Ensembl ID		ENSG00000111540	ENSG00000072274
Uniprot IDs		A0A024RB09 P61020	A8K6Q8 B7Z2I6 G3V0E5 P02786 Q7Z3E0
PDB IDs		2HEI	1CX8 1DE4 1SUV 2NSU 3KAS 3S9L 3S9M 3S9N 6D03 6D04 6D05 6GSR 6H5I
Enriched GO Terms of Interacting Partners?
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