WFDC1 and XRCC2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		WFDC1	XRCC2
Description		WAP four-disulfide core domain 1	X-ray repair cross complementing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Nucleoplasm Replication Fork Cytoplasm Centrosome Rad51B-Rad51C-Rad51D-XRCC2 Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Molecular_function Serine-type Endopeptidase Inhibitor Activity	Four-way Junction DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity
	Biological Process	Regulation Of Cell Growth Negative Regulation Of Endopeptidase Activity Negative Regulation Of Cell Growth Response To Estradiol Response To Drug Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Negative Regulation Of Wound Healing	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Somitogenesis DNA Repair Centrosome Cycle Response To X-ray Response To Gamma Radiation Multicellular Organism Growth Strand Invasion Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neurogenesis Meiotic Cell Cycle Regulation Of Fibroblast Apoptotic Process
Pathways			HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Systolic blood pressure (alcohol consumption interaction) ( 24376456) Visceral adipose tissue adjusted for BMI ( 22589738)	Diabetic kidney disease ( 26305897) Mean platelet volume ( 27863252) Palmitic acid (16:0) levels ( 23362303)
Interacting Genes		5 interacting genes: EZR FOSL1 RAB40B XRCC2 ZNF677	5 interacting genes: MEOX2 NKIRAS1 RAD51 RAD51D WFDC1
Entrez ID		58189	7516
HPRD ID		05614	02656
Ensembl ID		ENSG00000103175	ENSG00000196584
Uniprot IDs		Q9HC57	A0A384MEK2 O43543
PDB IDs
Enriched GO Terms of Interacting Partners?
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