PURB and PURA

Number of citations of the paper that reports this interaction (PubMedID 10318844)
30

Data Source:
HPRD (in vivo, in vitro)

		PURB	PURA
Description		purine rich element binding protein B	purine rich element binding protein A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor A Complex	Nuclear Chromosome, Telomeric Region Nucleus DNA Replication Factor A Complex Dendrite Cytoplasm Neuronal Cell Body Postsynapse Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding Transcription Factor Binding Purine-rich Negative Regulatory Element Binding Sequence-specific DNA Binding SMAD Binding	Translation Repressor Activity, MRNA Regulatory Element Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Double-stranded DNA Binding Double-stranded Telomeric DNA Binding Single-stranded DNA Binding RNA Binding Protein Binding Transcription Factor Binding Purine-rich Negative Regulatory Element Binding Sequence-specific DNA Binding SMAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Proliferation Cell Differentiation Regulation Of Myeloid Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II DNA Unwinding Involved In DNA Replication DNA Replication Initiation Nervous System Development Positive Regulation Of Cell Proliferation Negative Regulation Of Translation Cell Differentiation Lymphocyte Proliferation Epithelial Cell Proliferation Dendritic Transport Of Messenger Ribonucleoprotein Complex
Pathways
Drugs
Diseases
GWAS		Platelet count ( 27863252)	Body mass index ( 26426971)
Interacting Genes		3 interacting genes: CSNK2A1 IL7R PURA	10 interacting genes: ADAP1 CCNT1 CDK5 E2F1 IL7R PURB RAF1 RB1 SP1 YBX1
Entrez ID		5814	5813
HPRD ID		12325	02721
Ensembl ID		ENSG00000146676	ENSG00000185129
Uniprot IDs		Q96QR8	Q00577
PDB IDs
Enriched GO Terms of Interacting Partners?
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