KAT5 and HDAC7

Number of citations of the paper that reports this interaction (PubMedID 12551922)
34

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (in vivo)

		KAT5	HDAC7
Description		lysine acetyltransferase 5	histone deacetylase 7
Image
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nuclear Chromatin Swr1 Complex Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Piccolo NuA4 Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex Perinuclear Region Of Cytoplasm	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding H4 Histone Acetyltransferase Activity Acetyltransferase Activity Histone Binding Metal Ion Binding Androgen Receptor Binding Peptide-lysine-N-acetyltransferase Activity Repressing Transcription Factor Binding	Chromatin Binding Transcription Corepressor Activity Protein Kinase C Binding Protein Binding Protein Kinase Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Activating Transcription Factor Binding Metal Ion Binding Repressing Transcription Factor Binding 14-3-3 Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Double-strand Break Processing DNA Replication Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Response To Ionizing Radiation Positive Regulation Of Autophagy Viral Process Histone Acetylation Peptidyl-lysine Acetylation Androgen Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Regulation Of Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone H4 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Acetylation Beta-catenin-TCF Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Cell-cell Junction Assembly Negative Regulation Of Interleukin-2 Production Negative Regulation Of Osteoblast Differentiation Histone H3 Deacetylation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of NIK/NF-kappaB Signaling
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex DNA Damage/Telomere Stress Induced Senescence HATs acetylate histones HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Estrogen-dependent gene expression	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SUMOylation of DNA damage response and repair proteins Notch-HLH transcription pathway Regulation of PTEN gene transcription
Drugs		Coenzyme A S-Acetyl-Cysteine	7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4,6-Dimethyl-7-Oxo-2,4-Heptadienamide Belinostat Panobinostat
Diseases
GWAS		Acne (severe) ( 24927181) Asthma ( 31619474) Chronic kidney disease ( 20383146) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate ( 31152163) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Heel bone mineral density ( 30598549) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglycerides ( 30275531)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 30929738) Asthma (adult onset) ( 31036433 30929738) Bipolar disorder ( 31043756) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 27841878) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Obesity-related traits ( 23251661) Platelet count ( 27863252) Plateletcrit ( 27863252) Primary sclerosing cholangitis ( 23603763) Systolic blood pressure ( 27841878) Ulcerative colitis ( 28067908) Urate levels ( 23263486)
Interacting Genes		144 interacting genes: AGO2 ALOX12 ANTKMT APBB1 APLP1 APLP2 APP AR ARIH2 ATF3 ATM ATXN1 BARD1 BCL3 BMI1 BRCA1 C1orf174 CBX8 CCDC106 CCDC136 CCNB1 CCT7 CDC42 CDK1 CDK5RAP2 CDKN2A CEP126 CREB1 CREBBP CRELD1 CSTF2 DLEU1 DNAAF6 DUSP23 E2F1 EDNRA EFNA1 EP300 EP400 ESR1 ESR2 ETV6 FAM135B GADD45G GAPDH GEMIN7 GET4 GMCL1 GMCL2 GOLGA2 GSTO1 H2AC20 H2AC4 H2AX H3-3B H3-4 H3C1 H3C14 H4-16 H4C1 H4C14 HABP4 HAP1 HDAC1 HDAC7 HMBOX1 HNRNPH3 IK IKZF3 IL9R KLF4 KRT40 KRTAP10-3 KRTAP10-9 LMNA LONRF1 LRIF1 LRP1 LZTS2 MAD2L1BP MAPRE1 MCPH1 MDFI MDM2 MEOX2 MTUS2 MYC MYOD1 NAP1L5 NDUFA4L2 NDUFV2 NFKB1 NINL NR3C1 ODC1 OGFOD2 PDCD5 PFKP PHC2 PITX2 PLA2G4A PLEKHA4 PML POLE2 POLR3F PPARG PTPN4 PTPRS RB1 RCHY1 RELA RFLNB RGL2 RRM2 SAT1 SNAPIN SNRPD2 SOX5 SRF SRSF2 SSX2IP STAT3 STX11 SYN1 TBX5 TELO2 TMCC2 TNNT1 TP53 TRIB3 TRIM23 TRIM27 TRIM29 TRIM37 TUFT1 UHRF1 USP7 YIF1A YWHAG ZBTB14 ZBTB8A ZEB1 ZNF24 ZNF513	29 interacting genes: ACTN4 BCL6 CALCOCO2 CASP8 EDNRA EGFR GNMT HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 KAT5 MARK2 MARK3 MEF2A MEF2C NCOR2 PPARD PRKD1 PRKD2 REL RIPPLY1 RUNX2 SIN3A UBE2I YWHAG YWHAQ ZBTB16
Entrez ID		10524	51564
HPRD ID		03245	09133
Ensembl ID		ENSG00000172977	ENSG00000061273
Uniprot IDs		A0A024R597 A0A024R5E8 Q92993	Q8WUI4
PDB IDs		2EKO 2OU2 4QQG	3C0Y 3C0Z 3C10 3ZNR 3ZNS
Enriched GO Terms of Interacting Partners?
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