PTPRN2 and SPTBN4

Number of citations of the paper that reports this interaction (PubMedID 11086001)
102

Data Source:
HPRD (in vivo, two hybrid)

		PTPRN2	SPTBN4
Description		protein tyrosine phosphatase receptor type N2	spectrin beta, non-erythrocytic 4
Image			No pdb structure
GO Annotations	Cellular Component	Cell Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Integral Component Of Synaptic Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane Terminal Bouton Receptor Complex Ficolin-1-rich Granule Membrane	Cell Cytoplasm Cytosol Actin Filament Plasma Membrane Adherens Junction Spectrin Intercalated Disc Membrane Nuclear Matrix PML Body Node Of Ranvier Paranode Region Of Axon Neuronal Cell Body Axon Initial Segment Axon Hillock Extracellular Exosome Cell Body Fiber
	Molecular Function	Transmembrane Receptor Protein Tyrosine Phosphatase Activity	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipid Binding Phosphatase Binding Ankyrin Binding Spectrin Binding
	Biological Process	Protein Dephosphorylation Lipid Metabolic Process Neurotransmitter Secretion Negative Regulation Of GTPase Activity Peptidyl-tyrosine Dephosphorylation Insulin Secretion Involved In Cellular Response To Glucose Stimulus Neutrophil Degranulation	MAPK Cascade Regulation Of Sodium Ion Transport ER To Golgi Vesicle-mediated Transport Cytoskeletal Anchoring At Plasma Membrane Axonogenesis Axon Guidance Sensory Perception Of Sound Adult Walking Behavior Fertilization Negative Regulation Of Heart Rate Vesicle-mediated Transport Transmission Of Nerve Impulse Central Nervous System Projection Neuron Axonogenesis Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Multicellular Organism Growth Clustering Of Voltage-gated Sodium Channels Actin Filament Capping Cardiac Conduction Protein Localization To Plasma Membrane
Pathways		Neutrophil degranulation	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
Drugs
Diseases
GWAS		Bipolar disorder and schizophrenia ( 21057379) Breast cancer in childhood cancer survivors ( 29059430) Breast cancer in childhood cancer survivors treated with more than 10 gray radiotherapy ( 29059430) Calcium levels ( 25972035) Carotid plaque burden ( 28282560) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Diastolic blood pressure ( 27841878) Inflammatory skin disease ( 25574825) Intelligence (MTAG) ( 29326435) Myopia (pathological) ( 23049088) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Obesity-related traits ( 23251661) Plasma anti-thyroid peroxidase levels ( 29678681) Response to amphetamines ( 22952603) Serum metabolite concentrations in chronic kidney disease ( 29545352) Triacylglyceride levels ( 31551469)	Antibody level in response to infection ( 25758998) Pulse pressure ( 30578418)
Interacting Genes		3 interacting genes: CKAP5 SPTBN4 UBQLN4	14 interacting genes: ANK3 CDC37 CELSR3 CENPU CLK1 DISC1 GADD45A GSK3B NEK2 PFDN1 PTPRN PTPRN2 RPS6KA6 SPTAN1
Entrez ID		5799	57731
HPRD ID		03413	09372
Ensembl ID		ENSG00000155093	ENSG00000160460
Uniprot IDs		E7EM83 I6L9F8 Q92932	Q9H254
PDB IDs		2QEP 4HTI 4HTJ
Enriched GO Terms of Interacting Partners?
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