PTPRJ and HOXC6

Number of citations of the paper that reports this interaction (PubMedID 25640309)
5

Data Source:
BioGRID (two hybrid)

		PTPRJ	HOXC6
Description		protein tyrosine phosphatase receptor type J	homeobox C6
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Ruffle Membrane Specific Granule Membrane Extracellular Exosome	Nuclear Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Tyrosine Phosphatase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Activity Protein Kinase Binding Gamma-catenin Binding Cadherin Binding Mitogen-activated Protein Kinase Binding Delta-catenin Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Activity
	Biological Process	Protein Dephosphorylation Negative Regulation Of Cell Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion B Cell Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Positive Regulation Of Tumor Necrosis Factor Production Peptidyl-tyrosine Dephosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Neutrophil Degranulation Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Adhesion Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Contact Inhibition Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis	Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Anterior/posterior Pattern Specification Embryonic Skeletal System Development Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		Phosphorylation of CD3 and TCR zeta chains Neutrophil degranulation Negative regulation of MET activity
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576) D-dimer levels ( 21502573) Experiencing mood swings ( 29500382) Heel bone mineral density ( 30598549) Height ( 28552196 25282103 23563607) Hypertension ( 31879980) Intraocular pressure ( 29617998 25173106 31798171 29785010 31959993 30054594 29235454) Offspring birth weight ( 31043758) Sleep duration (short sleep) ( 30846698)	Hippocampal volume ( 25625606) Lumbar spine bone mineral density ( 22504420) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Waist circumference ( 28552196) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28552196 28448500) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		20 interacting genes: BAP1 CASC3 CTNNB1 CTNND1 CYP17A1 EGFR EPSTI1 HOXC6 IL2RG JUP KLK7 KLK9 LAT LYPD3 MET NOP2 PDGFRB PLCG1 PRDM14 SDCBP	10 interacting genes: APC APP BCAR3 BRD2 CHEK2 FGFR2 HMGB1 IGF1R PTPRJ TGFB1
Entrez ID		5795	3223
HPRD ID		02955	00858
Ensembl ID		ENSG00000149177	ENSG00000197757
Uniprot IDs		Q12913 Q9NPR5	P09630
PDB IDs		2CFV 2DLE 2NZ6
Enriched GO Terms of Interacting Partners?
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