PTPRJ and CTNND1

Number of citations of the paper that reports this interaction (PubMedID 12370829)
26

Data Source:
BioGRID (enzymatic study)
HPRD (in vivo, in vitro)

		PTPRJ	CTNND1
Description		protein tyrosine phosphatase receptor type J	catenin delta 1
Image
GO Annotations	Cellular Component	Immunological Synapse Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Ruffle Membrane Specific Granule Membrane Extracellular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Catenin Complex Lamellipodium Growth Cone Midbody Dendritic Spine Extracellular Exosome Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Protein Tyrosine Phosphatase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Activity Protein Kinase Binding Gamma-catenin Binding Cadherin Binding Mitogen-activated Protein Kinase Binding Delta-catenin Binding	Signaling Receptor Binding Protein Binding Protein Kinase Binding Cadherin Binding
	Biological Process	Protein Dephosphorylation Negative Regulation Of Cell Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion B Cell Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Positive Regulation Of Tumor Necrosis Factor Production Peptidyl-tyrosine Dephosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Neutrophil Degranulation Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Adhesion Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Contact Inhibition Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis	Cell-cell Junction Assembly Brain Development Wnt Signaling Pathway Adherens Junction Organization Entry Of Bacterium Into Host Cell Cell-cell Adhesion Mediated By Cadherin Protein Stabilization Negative Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		Phosphorylation of CD3 and TCR zeta chains Neutrophil degranulation Negative regulation of MET activity	Adherens junctions interactions VEGFR2 mediated vascular permeability InlA-mediated entry of Listeria monocytogenes into host cells
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576) D-dimer levels ( 21502573) Experiencing mood swings ( 29500382) Heel bone mineral density ( 30598549) Height ( 28552196 25282103 23563607) Hypertension ( 31879980) Intraocular pressure ( 29617998 25173106 31798171 29785010 31959993 30054594 29235454) Offspring birth weight ( 31043758) Sleep duration (short sleep) ( 30846698)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Household income (MTAG) ( 31844048) Neuroticism ( 29255261) Parkinson's disease ( 27182965) Pulse pressure ( 27841878 30578418) Schizophrenia ( 25056061 29483656) Systolic blood pressure ( 27841878)
Interacting Genes		20 interacting genes: BAP1 CASC3 CTNNB1 CTNND1 CYP17A1 EGFR EPSTI1 HOXC6 IL2RG JUP KLK7 KLK9 LAT LYPD3 MET NOP2 PDGFRB PLCG1 PRDM14 SDCBP	29 interacting genes: ACTA1 APP CDH1 CDH24 CDH3 CDH5 COL17A1 CTTN EGFR ERBIN FER GRIK2 GSK3B JUP KCTD6 LCK MTNR1B MUC1 PLPP3 PSEN1 PTPN6 PTPRJ PTPRM RPS6KA3 SNCA SRC SUMO2 YWHAG ZBTB33
Entrez ID		5795	1500
HPRD ID		02955	03026
Ensembl ID		ENSG00000149177	ENSG00000198561
Uniprot IDs		Q12913 Q9NPR5	O60716
PDB IDs		2CFV 2DLE 2NZ6	3L6X 3L6Y
Enriched GO Terms of Interacting Partners?
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