PTPRD and EPHA8

Number of citations of the paper that reports this interaction (PubMedID 22305495)
16

Data Source:
BioGRID (pull down)

		PTPRD	EPHA8
Description		protein tyrosine phosphatase receptor type D	EPH receptor A8
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome Glutamatergic Synapse	Plasma Membrane Integral Component Of Plasma Membrane Early Endosome Membrane Neuron Projection Receptor Complex
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Signaling Receptor Binding Protein Binding Cell Adhesion Molecule Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding
	Biological Process	Protein Dephosphorylation Phosphate-containing Compound Metabolic Process Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Neuron Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Dendrite Morphogenesis Positive Regulation Of Synapse Assembly Presynaptic Membrane Assembly Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion Regulation Of Presynapse Assembly	Substrate-dependent Cell Migration Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Neuron Remodeling Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Neuron Projection Development Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway Cellular Response To Follicle-stimulating Hormone Stimulus
Pathways		Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs
Diseases
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Airflow obstruction ( 22837378) Anxiety and major depressive disorder ( 24047446) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Bitter alcoholic beverage consumption ( 31046077) Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) Cardiac Troponin-T levels ( 31014085) Cerebrospinal P-tau181p levels ( 28247064) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Early age at menarche ( 29773799) Endometrial cancer (endometrioid histology) ( 30093612) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Epilepsy (remission after treatment) ( 23962720) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Gait rhythm ( 26219847) Glycine levels ( 31070104) Gout ( 22179738) Heel bone mineral density ( 30598549) Immune response to measles-mumps-rubella vaccine ( 24811271) Intracranial aneurysm ( 29531279) Lean body mass ( 28552196) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Loneliness (multivariate analysis) ( 27629369) Low susceptibility to hepatitis C infection ( 31206233) Menarche (age at onset) ( 29773799 25231870) Metabolite levels ( 23823483) Midgestational circulating levels of PCBs (fetal genetic effect) ( 28235828) Moderate-to-late spontaneous preterm birth ( 31194736) Modic changes ( 30808802) Mood instability ( 29187730) Morning person ( 30696823) Myopia (pathological) ( 23049088) Non-alcoholic fatty liver disease activity score ( 31311600) Non-response to antidepressants and depression ( 27622933) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 24821223) Palmitic acid (16:0) levels ( 23362303) Partial epilepsies ( 20522523) Pelvic organ prolapse (moderate/severe) ( 26545240) Personality dimensions ( 23903073) Pit-and-Fissure caries ( 24556642) Plasma clusterin levels ( 26545630) Platelet aggregation ( 20526338) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pulse pressure ( 27841878) Pursuit maintenance gain ( 29064472) Resistant hypertension ( 30237584) Resting-state electroencephalogram vigilance ( 29703947) Restless legs syndrome ( 18660810 29029846 21779176) Short-term memory (digit-span task) ( 30741946) Subcutaneous adipose tissue ( 26480920) Systolic blood pressure ( 30224653 27841878) Temperament ( 22832960) Third ventricle volume ( 31530798) Type 2 diabetes ( 21647700 20174558) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) White matter hyperintensities in ischemic stroke ( 26674333)
Interacting Genes		33 interacting genes: ABLIM1 AURKA BMX CSNK1D CSNK1E DDX17 DDX54 EPHA8 GPC4 IL1RAP IRS1 MARK2 MATK MTNR1A MTNR1B MTSS1 NEK1 NEK2 NEK6 PAK6 PLK1 PPFIA1 PPFIA2 PPFIA3 PTPRA PTPRE PTPRF PTPRS SCEL SLAIN2 SMTNL2 TBK1 TSSK2	12 interacting genes: AK4 DARS2 EFNA1 EFNA4 EFNA5 FYN G3BP1 LRRK1 PIK3CG PSMC5 PTPRD ZNF746
Entrez ID		5789	2046
HPRD ID		03358	01493
Ensembl ID		ENSG00000153707	ENSG00000070886
Uniprot IDs		P23468 Q2HXI4 Q3KPI9 Q59H90	P29322
PDB IDs		1X5Z 2DLH 2YD6 2YD7 4RCA 5WY8 5XNP	1UCV 1X5L 3KUL
Enriched GO Terms of Interacting Partners?
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