LSM2 and LSM6

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (biochemical, affinity chromatography technology)
HPRD (in vitro)

		LSM2	LSM6
Description		LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
Image
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm U6 SnRNP Cytoplasm Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex	P-body Nucleus Nucleoplasm U6 SnRNP Nucleolus Small Nucleolar Ribonucleoprotein Complex Cytoplasm Cytosol Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Lsm2-8 Complex
	Molecular Function	RNA Binding Protein Binding U6 SnRNA Binding Ral GTPase Binding	RNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly MRNA Splicing, Via Spliceosome MRNA Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	MRNA Splicing, Via Spliceosome MRNA Catabolic Process TRNA Processing RNA Splicing Maturation Of SSU-rRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs			Uridine Uridine monophosphate Citric Acid
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Inflammatory bowel disease ( 28067908) Rosacea symptom severity ( 29771307) Ulcerative colitis ( 28067908)	Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)
Interacting Genes		33 interacting genes: BANP CLNS1A CRMP1 DDX20 DNAJA1 ERG28 EXOSC10 GBP2 KRT13 LNX1 LSM1 LSM3 LSM5 LSM6 LSM7 LSM8 MAGEA6 MEOX2 PNMA1 PRCC RALA REL RSRC1 SF3B2 SMN1 SNRPB SNRPD2 SNRPE TEX11 TLE5 TRIM54 ZBTB16 ZNF408	14 interacting genes: APP LSM1 LSM2 LSM3 LSM5 LSM7 LSM8 MCRS1 POLD2 SDCBP SMN1 SNRPD2 SNRPF TARDBP
Entrez ID		57819	11157
HPRD ID		06282	06286
Ensembl ID		ENSG00000204392	ENSG00000164167
Uniprot IDs		Q9Y333	P62312
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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