PREX1 and ITSN1

Number of citations of the paper that reports this interaction (PubMedID 22558309)
18

Data Source:
BioGRID (two hybrid)

		PREX1	ITSN1
Description		phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1	intersectin 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Growth Cone Dendritic Shaft Perinuclear Region Of Cytoplasm	Nuclear Envelope Cytosol Plasma Membrane Clathrin-coated Pit Lamellipodium Cell Junction Endocytic Vesicle Neuronal Cell Body Dendritic Spine Calyx Of Held Recycling Endosome Apical Dendrite Presynaptic Endocytic Zone Postsynaptic Actin Cytoskeleton Glutamatergic Synapse
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Phospholipid Binding Enzyme Binding Rac Guanyl-nucleotide Exchange Factor Activity	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Kinase Activator Activity Molecular Adaptor Activity Proline-rich Region Binding
	Biological Process	Superoxide Metabolic Process G Protein-coupled Receptor Signaling Pathway Actin Filament Polymerization T Cell Differentiation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Regulation Of Actin Filament Polymerization Intracellular Signal Transduction Neutrophil Activation Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Dendrite Development Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Exocytosis G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Brain Development Protein Transport Viral Process Positive Regulation Of Kinase Activity Cellular Protein Localization Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Synaptic Vesicle Endocytosis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Dendritic Spine Development Membrane Organization Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Caveolin-mediated Endocytosis
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events	NRAGE signals death through JNK Rho GTPase cycle EPHB-mediated forward signaling EPHB-mediated forward signaling G alpha (12/13) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Colorectal cancer ( 30529582 26151821) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 28135244 27841878 27618447) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Multiple myeloma ( 27363682) Nephrotic syndrome (acquired) ( 21441931) Response to selective serotonin reuptake inhibitors in depression ( 30034349) Tonometry ( 17903302) Waist circumference ( 28552196)	Bitter non-alcoholic beverage consumption ( 31046077) Educational attainment ( 25201988) Height ( 31562340) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) QT interval ( 29213071) Red cell distribution width ( 27863252) Tonsillectomy ( 27182965 28928442)
Interacting Genes		3 interacting genes: ITSN1 MTOR PPP1CA	85 interacting genes: AGFG1 AGFG2 AP2B1 ARF6 ARFIP2 ARHGAP31 ASAP2 CCNO CDC42 CEP85L CLIP2 CLTC CSNK2B CYTH1 DAB2 DES DISC1 DLGAP1 DNM1 DNM2 EEF1A1 EPHB2 EPN2 EPS15 EPS15L1 FCHO1 FCHO2 FCHSD2 FNBP1 FNBP4 GAREM2 GCC1 GOLGA5 HIP1 HRAS ITSN2 KHDRBS1 KIF16B KIF5A LMO4 MAP3K20 MAPK6 MAPK8IP2 MRPL20 MTUS2 PACSIN3 PDCD6IP PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 RAB11FIP2 RAB5A RABEP1 RAI14 RNF40 RPS6KA5 SCAMP1 SCOC SF3B4 SGIP1 SH3GL2 SMARCC2 SNAP23 SNAP25 SNX5 SOS1 SPDL1 SPRY2 STON2 SYNJ1 SYNJ2 TK1 TRIM8 TSG101 UBE2K UNC119 WASL WBP11 ZFPM2
Entrez ID		57580	6453
HPRD ID		06066	03898
Ensembl ID		ENSG00000124126	ENSG00000205726
Uniprot IDs		Q8TCU6	A7XZY7 F8W7U0 Q15811 Q6PD56
PDB IDs		3QIK 4YON 5D27 5D3V 5D3W 5D3X 5D3Y 5FI0 5FI1	1KI1 2KGR 2KHN 3FIA 3QBV 4IIM 5HZI 5HZJ 5HZK 6GBU 6H5T
Enriched GO Terms of Interacting Partners?
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