PREX1

Description		phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Growth Cone Dendritic Shaft Perinuclear Region Of Cytoplasm
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Phospholipid Binding Enzyme Binding Rac Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Superoxide Metabolic Process G Protein-coupled Receptor Signaling Pathway Actin Filament Polymerization T Cell Differentiation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Regulation Of Actin Filament Polymerization Intracellular Signal Transduction Neutrophil Activation Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Dendrite Development Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Colorectal cancer ( 30529582 26151821) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 28135244 27841878 27618447) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Multiple myeloma ( 27363682) Nephrotic syndrome (acquired) ( 21441931) Response to selective serotonin reuptake inhibitors in depression ( 30034349) Tonometry ( 17903302) Waist circumference ( 28552196)
Interacting Genes		3 interacting genes: ITSN1 MTOR PPP1CA
Entrez ID		57580
HPRD ID		06066
Ensembl ID		ENSG00000124126
Uniprot IDs		Q8TCU6
PDB IDs		3QIK 4YON 5D27 5D3V 5D3W 5D3X 5D3Y 5FI0 5FI1
Enriched GO Terms of Interacting Partners?
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