SPC25 and SEC61B

Number of citations of the paper that reports this interaction (PubMedID 9585408)
37

Data Source:
HPRD (in vivo)

		SPC25	SEC61B
Description		SPC25 component of NDC80 kinetochore complex	SEC61 translocon subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleus Cytosol Ndc80 Complex	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Endoplasmic Reticulum Sec Complex
	Molecular Function	Protein Binding	RNA Binding ARF Guanyl-nucleotide Exchange Factor Activity Protein Binding Epidermal Growth Factor Binding
	Biological Process	Mitotic Spindle Organization Chromosome Segregation Cell Division	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Posttranslational Protein Targeting To Membrane, Translocation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Fasting blood glucose ( 29621232) Glycemic traits (pleiotropy) ( 31021400) Granulocyte count ( 27863252) Height ( 28552196) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Metabolite levels ( 23823483) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)	Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		2 interacting genes: NDC80 SEC61B	11 interacting genes: APOB ARL6 ATP13A2 BAG6 GET3 GET4 SEC63 SERP1 SPC25 TRAM1 UBL4A
Entrez ID		57405	10952
HPRD ID		15465	06715
Ensembl ID		ENSG00000152253	ENSG00000106803
Uniprot IDs		Q9HBM1	P60468
PDB IDs		2VE7 3IZ0
Enriched GO Terms of Interacting Partners?
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