SEC61B and SPC25

Number of citations of the paper that reports this interaction (PubMedID 9585408)
37

Data Source:
HPRD (in vivo)

		SEC61B	SPC25
Description		SEC61 translocon subunit beta	SPC25 component of NDC80 kinetochore complex
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Endoplasmic Reticulum Sec Complex	Condensed Chromosome Kinetochore Nucleus Cytosol Ndc80 Complex
	Molecular Function	RNA Binding ARF Guanyl-nucleotide Exchange Factor Activity Protein Binding Epidermal Growth Factor Binding	Protein Binding
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Posttranslational Protein Targeting To Membrane, Translocation	Mitotic Spindle Organization Chromosome Segregation Cell Division
Pathways		ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Callous-unemotional behaviour ( 23874384) Gestational age at birth (maternal effect) ( 28877031) Smoking status (ever vs never smokers) ( 30643258)	Fasting blood glucose ( 29621232) Glycemic traits (pleiotropy) ( 31021400) Granulocyte count ( 27863252) Height ( 28552196) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Metabolite levels ( 23823483) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)
Interacting Genes		11 interacting genes: APOB ARL6 ATP13A2 BAG6 GET3 GET4 SEC63 SERP1 SPC25 TRAM1 UBL4A	2 interacting genes: NDC80 SEC61B
Entrez ID		10952	57405
HPRD ID		06715	15465
Ensembl ID		ENSG00000106803	ENSG00000152253
Uniprot IDs		P60468	Q9HBM1
PDB IDs			2VE7 3IZ0
Enriched GO Terms of Interacting Partners?
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