RAB25 and BMPR1B

Number of citations of the paper that reports this interaction (PubMedID 15761153)
246

Data Source:
HPRD (in vivo)

		RAB25	BMPR1B
Description		RAB25, member RAS oncogene family	bone morphogenetic protein receptor type 1B
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GO Annotations	Cellular Component	Endosome Endomembrane System Pseudopodium Pseudopodium Membrane Cytoplasmic Vesicle Recycling Endosome Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding Myosin V Binding	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding SMAD Binding Metal Ion Binding
	Biological Process	Epithelial Cell Morphogenesis Intracellular Protein Transport Exocytosis Positive Regulation Of Cell Proliferation Positive Regulation Of Epithelial Cell Migration Pseudopodium Organization Rab Protein Signal Transduction Regulation Of Vesicle-mediated Transport	Skeletal System Development Cartilage Condensation Ovarian Cumulus Expansion Eye Development Chondrocyte Development Protein Phosphorylation Inflammatory Response Dorsal/ventral Pattern Formation Proteoglycan Biosynthetic Process Positive Regulation Of Bone Mineralization BMP Signaling Pathway Retinal Ganglion Cell Axon Guidance Positive Regulation Of Chondrocyte Differentiation Limb Morphogenesis Ovulation Cycle Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Retina Development In Camera-type Eye Endochondral Bone Morphogenesis Positive Regulation Of Cartilage Development Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Chondrocyte Proliferation
Pathways		RAB geranylgeranylation	Signaling by BMP
Drugs
Diseases			Acromesomelic dysplasia with genital anomalies Brachydactyly, including: type A; type B; type D; type E
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Attention deficit hyperactivity disorder ( 20732626) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Diverticular disease ( 30177863) Heel bone mineral density ( 30598549) Hen's egg allergy ( 29051540) Prepulse inhibition of the startle response ( 31596458) Schizophrenia ( 30470734) Systolic blood pressure ( 30224653 30578418) Waist-hip ratio ( 28552196)
Interacting Genes		13 interacting genes: ACVR1 BMPR1B ITGB1 MED31 MYO5B OPTN RAB11FIP1 RAB11FIP2 RAB11FIP3 RAB11FIP5 SMAD4 SMURF2 TGFBR1	64 interacting genes: AMHR2 APP ARHGEF6 BAMBI BMP15 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR2 CDK14 CDK4 CHN1 DCAF12 DCAF6 DCAF7 FANCL GDF5 GDF6 GDF9 KLHL1 LZTR1 NKIRAS1 OTUB1 OXSR1 PAK1 PLEKHB1 POMK PPP2CA PPP3CC RAB25 RAB38 RAB6B RAN RAP2A RASD2 RASL12 RHEBL1 RHOD RHOJ RPS27A RRAS2 SASH3 SH3KBP1 SMAD6 SMAD7 SNX6 SOCS6 SQSTM1 SRGAP1 STAMBP STK35 STUB1 TGFBR1 TNNT1 TRAF6 TTC17 TTC27 UBA52 UBE2Z UBXN1 USP45 VEPH1
Entrez ID		57111	658
HPRD ID		06698	04457
Ensembl ID		ENSG00000132698	ENSG00000138696
Uniprot IDs		P57735	A8KAE3 O00238
PDB IDs		2OIL 3TSO	3MDY
Enriched GO Terms of Interacting Partners?
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