MASP1 and UFD1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		MASP1	UFD1
Description		mannan binding lectin serine peptidase 1	ubiquitin recognition factor in ER associated degradation 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Protein Homodimerization Activity Calcium-dependent Protein Binding	Thiol-dependent Ubiquitin-specific Protease Activity Signaling Receptor Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Protein-containing Complex Binding ATPase Binding
	Biological Process	Complement Activation, Lectin Pathway Proteolysis Receptor-mediated Endocytosis Complement Activation	Skeletal System Development Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway Error-free Translesion Synthesis ER-associated Misfolded Protein Catabolic Process
Pathways		Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface Scavenging by Class A Receptors	Translesion Synthesis by POLH Ub-specific processing proteases
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 30072576) Impulsivity (attentional) ( 30718321) Type 2 diabetes ( 30130595)
Interacting Genes		16 interacting genes: C2 C3 FCN2 GADD45A GSK3B H2AX MAPK6 MAPK8IP2 MAPT MBL2 NCK2 NUDT21 RPS6KA3 RPS6KA6 SERPING1 UFD1	23 interacting genes: A2M AMFR ANAPC2 CHMP2A F13A1 GZMK HSPB1 IGHM LRRK2 MAP3K1 MASP1 NGFR NPLOC4 NUB1 PIK3CA PPHLN1 SNX1 TAF1C TIAM2 TP53 UBC UBXN6 VCP
Entrez ID		5648	7353
HPRD ID		02749	06778
Ensembl ID		ENSG00000127241	ENSG00000070010
Uniprot IDs		F8W876 P48740	Q541A5 Q92890
PDB IDs		3DEM 3GOV 4AQB 4DJZ 4IGD 4IW4 4KKD	2YUJ 5B6C 5C1B
Enriched GO Terms of Interacting Partners?
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