MASP1 and MBL2

Number of citations of the paper that reports this interaction (PubMedID 10878362)
16

Data Source:
HPRD (in vivo)

		MASP1	MBL2
Description		mannan binding lectin serine peptidase 1	mannose binding lectin 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytosol	Extracellular Region Collagen Trimer Extracellular Space Cell Surface Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Protein Homodimerization Activity Calcium-dependent Protein Binding	Signaling Receptor Binding Protein Binding Mannose Binding Calcium-dependent Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Proteolysis Receptor-mediated Endocytosis Complement Activation	Complement Activation, Lectin Pathway Growth Plate Cartilage Chondrocyte Morphogenesis Acute-phase Response Complement Activation Complement Activation, Classical Pathway Response To Oxidative Stress Opsonization Defense Response To Bacterium Innate Immune Response Negative Regulation Of Viral Process Positive Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Killing By Host Of Symbiont Cells
Pathways		Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface Scavenging by Class A Receptors	Lectin pathway of complement activation Initial triggering of complement
Drugs			O3-Sulfonylgalactose Methyl alpha-D-mannoside O4-Sulfonylgalactose beta-L-methyl-fucose N-acetyl-alpha-neuraminic acid alpha-L-methyl-fucose Alpha-Methyl-N-Acetyl-D-Glucosamine
Diseases			Mannose-binding lectin pathway component defects, including the following two diseases: Mannose-binding lectin deficiency; Mannose-binding lectin-associated serine protease (MASP) 2 deficiency Tuberculosis
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 30072576) Impulsivity (attentional) ( 30718321) Type 2 diabetes ( 30130595)	Age-related macular degeneration ( 23326517) Blood protein levels ( 30072576 29875488 28240269) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chin dimples ( 27182965) Emphysema imaging phenotypes ( 26030696) Femoral neck bone mineral density ( 29499414) Fractures ( 30158200 30598549) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414 22504420) Metabolite levels ( 23823483) Monobrow ( 27182965) Rosacea symptom severity ( 29771307)
Interacting Genes		16 interacting genes: C2 C3 FCN2 GADD45A GSK3B H2AX MAPK6 MAPK8IP2 MAPT MBL2 NCK2 NUDT21 RPS6KA3 RPS6KA6 SERPING1 UFD1	8 interacting genes: CALCR CALR CD93 KRT1 MAD2L1 MASP1 MASP2 PTPRC
Entrez ID		5648	4153
HPRD ID		02749	01107
Ensembl ID		ENSG00000127241	ENSG00000165471
Uniprot IDs		F8W876 P48740	P11226
PDB IDs		3DEM 3GOV 4AQB 4DJZ 4IGD 4IW4 4KKD	1HUP
Enriched GO Terms of Interacting Partners?
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