PRNP and BRD2

		PRNP	BRD2
Description		prion protein	bromodomain containing 2
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GO Annotations	Cellular Component	Cell Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Cell Surface Postsynaptic Density Inclusion Body Extrinsic Component Of Membrane Dendrite Anchored Component Of External Side Of Plasma Membrane Nuclear Membrane Terminal Bouton Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Exosome Postsynapse	Nucleoplasm Cytoplasm Nuclear Speck
	Molecular Function	Amyloid-beta Binding Protease Binding Copper Ion Binding Calcium Ion Binding Protein Binding Lamin Binding Glycosaminoglycan Binding Microtubule Binding Tubulin Binding Aspartic-type Endopeptidase Inhibitor Activity Type 5 Metabotropic Glutamate Receptor Binding Type 8 Metabotropic Glutamate Receptor Binding Signaling Receptor Activity Identical Protein Binding ATP-dependent Protein Binding Ion Channel Binding Protein-containing Complex Binding Chaperone Binding Cupric Ion Binding Cuprous Ion Binding	Chromatin Binding Protein Binding Lysine-acetylated Histone Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Cellular Copper Ion Homeostasis Response To Oxidative Stress Cell Cycle Arrest Learning Or Memory Long-term Memory Negative Regulation Of Endopeptidase Activity Negative Regulation Of Protein Processing Protein Destabilization Activation Of Protein Kinase Activity Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Calcium-mediated Signaling Using Intracellular Calcium Source Cellular Response To Drug Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Activated T Cell Proliferation Response To Cadmium Ion Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of T Cell Receptor Signaling Pathway Protein Homooligomerization Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Copper Ion Positive Regulation Of Protein Targeting To Membrane Modulation Of Age-related Behavioral Decline Dendritic Spine Maintenance Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Neuron Death Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Amyloid-beta Formation Regulation Of Intracellular Calcium Activated Chloride Channel Activity Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Localization To Plasma Membrane Response To Amyloid-beta Cellular Response To Amyloid-beta Regulation Of Calcium Ion Import Across Plasma Membrane Neuron Projection Maintenance	Neural Tube Closure Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Spermatogenesis Viral Process
Pathways		NCAM1 interactions Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	RUNX3 regulates p14-ARF
Drugs		Tetracycline Copper
Diseases		Prion diseases; Creutzfeldt-Jacob disease (CJD); Gerstmann-Straussler disease (GSD); Gerstmann-Straussler-Scheinker disease (GSSD); Fatal familial insomnia (FFI)
GWAS		Creutzfeldt-Jakob disease ( 19081515) Creutzfeldt-Jakob disease (sporadic) ( 25918841) Creutzfeldt-Jakob disease (variant) ( 22137330) KANNO antigen negativity ( 31020675) Platelet aggregation ( 20526338) Prion diseases ( 22210626) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI (smoking interaction) ( 28443625)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 28008999) Feeling nervous ( 29500382) Inflammatory bowel disease ( 28008999) Ulcerative colitis ( 28008999)
Interacting Genes		93 interacting genes: ABT1 ADAM23 ADAP2 AGO1 AIFM3 APBB1 APLP1 APLP2 APOE ARHGAP15 ATIC ATP6V1B2 BAG6 BAZ2B BRD2 C7orf50 CAV1 CCDC149 CIRBP CLSTN1 CLU CNP CNTN1 CRYAB CSN3 CSNK2A1 CSNK2A2 CSNK2B CWC15 DDX47 DNM1 DOCK7 DPP6 DYRK3 ERI3 FAM27E3 FBLN5 FBXO45 FGF13 FHL1 GRB2 HAX1 HSPA5 HSPD1 IER3 KIAA1191 KIFAP3 L1CAM LMNA LSAMP MAG MARK4 MMADHC MOG MTG1 NCAM1 NCAM2 NECTIN1 NHP2 NIPSNAP2 NOB1 OPCML P4HB PDE4DIP PLG PPFIBP2 PPP1R14A PSMA3 PSMB5 PTRH1 PYM1 RBM22 RNPC3 RPL41 SCNM1 SEC31A SPARCL1 STARD5 STIP1 SURF2 TBPL1 TMEM237 TRIM15 TSC22D4 TSLP TYMSOS UTP4 WDR5 WDR61 ZFYVE28 ZKSCAN8 ZNF408 ZNF740	17 interacting genes: CDC42EP4 CLCN2 DDR1 E2F1 E2F2 ECEL1 H2BC21 H2BU1 H4-16 HLA-DQA1 HOXC6 PHF1 PRNP PSMB9 RAC2 SPOP TBP
Entrez ID		5621	6046
HPRD ID		01453	03326
Ensembl ID		ENSG00000171867	ENSG00000204256
Uniprot IDs		F7VJQ1 P04156 Q53YK7	A0A024RCR5 A0A1U9X7A8 P25440 X5CF57
PDB IDs		1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1OEH 1OEI 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 2IV4 2IV5 2IV6 2K1D 2KUN 2LBG 2LEJ 2LFT 2LSB 2LV1 2M8T 2OL9 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 3MD4 3MD5 3NHC 3NHD 3NVF 4DGI 4E1H 4E1I 4KML 4N9O 5L6R 5YJ4 5YJ5 6DU9	1X0J 2DVQ 2DVR 2DVS 2DVV 2E3K 2G4A 2YDW 2YEK 3AQA 3ONI 4A9E 4A9F 4A9H 4A9I 4A9J 4A9M 4A9N 4A9O 4AKN 4ALG 4ALH 4J1P 4MR5 4MR6 4QEU 4QEV 4QEW 4UYF 4UYG 4UYH 5BT5 5DFB 5DFC 5DFD 5DW1 5EK9 5HEL 5HEM 5HEN 5HFQ 5IBN 5IG6 5N2L 5O38 5O39 5O3A 5O3B 5O3C 5O3D 5O3E 5O3F 5O3G 5O3H 5O3I 5U5S 5U6V 5UEW 5XHE 5XHK 6CUI 6DB0 6DBC 6DDI 6DDJ 6E6J 6FFE 6FFF 6FFG 6I80 6I81 6K04 6K05 6MO7 6MO8 6MO9 6MOA
Enriched GO Terms of Interacting Partners?
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