CCNDBP1 and SPG7

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CCNDBP1	SPG7
Description		cyclin D1 binding protein 1	SPG7 matrix AAA peptidase subunit, paraplegin
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body	Mitochondrion Mitochondrial Inner Membrane M-AAA Complex Mitochondrial Permeability Transition Pore Complex Axon Cytoplasm
	Molecular Function	Protein Binding	Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Zinc Ion Binding Unfolded Protein Binding
	Biological Process	Cell Cycle Regulation Of Cell Cycle	Proteolysis Mitochondrial Calcium Ion Transmembrane Transport Mitochondrion Organization Nervous System Development Anterograde Axonal Transport Regulation Of Mitochondrial Membrane Permeability Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death
Pathways			Processing of SMDT1
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS			Hair morphology traits ( 30166351) Heel bone mineral density ( 30598549) Type 2 diabetes ( 30297969) White coat effect (clinic systolic blood pressure minus ambulatory systolic blood pressure) ( 31044621)
Interacting Genes		81 interacting genes: AMPD2 ARHGAP22 ATP4B C22orf23 C6orf226 CCDC146 CCND1 CDK18 CDKN2A CFAP65 CNNM3 CUL5 DMRT3 DOCK2 FAM110A FAM126A FAM161A FAM74A4 FH GLIDR GRAP2 GSTK1 HSPB1 ILF2 IMP3 MAP2K2 MOS MRPL15 MRPS9 MTDH NAIF1 NANOS2 NEURL3 NUDCD3 PAXIP1 PIAS2 PIMREG PMP2 PRPF31 PSMB10 PTF1A RBP5 RPL28 RPL39L RPLP0 RPS28 SASH1 SIRT6 SPG7 STK25 SYF2 TEAD4 TFPT THAP10 THAP7 TMEM120B TRAPPC5 TTC23 TYMSOS ZBTB24 ZGPAT ZNF124 ZNF136 ZNF169 ZNF20 ZNF230 ZNF334 ZNF394 ZNF417 ZNF439 ZNF440 ZNF490 ZNF555 ZNF564 ZNF581 ZNF627 ZNF670 ZNF697 ZNF707 ZNRF2P1 ZSCAN26	25 interacting genes: CCNDBP1 HNRNPK KHDRBS2 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP4-12 KRTAP5-9 LRIF1 LZTS2 MAPK6 MDFI MTUS2 NOTCH2NLA PLSCR1 PNMA1 PSME3 PSTPIP1 RALY RBPMS SASH1 SPATS1 STAMBP TRIM28
Entrez ID		23582	6687
HPRD ID		06156	04149
Ensembl ID		ENSG00000166946	ENSG00000197912
Uniprot IDs		O95273	A0A2R8Y632 Q9UQ90
PDB IDs		3AY5	2QZ4
Enriched GO Terms of Interacting Partners?
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