PRKCG and NOXA1

Number of citations of the paper that reports this interaction (PubMedID 16713569)
313

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRKCG	NOXA1
Description		protein kinase C gamma	NADPH oxidase activator 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Cell-cell Junction Postsynaptic Density Dendrite Calyx Of Held Perinuclear Region Of Cytoplasm Synaptic Membrane Presynaptic Cytosol Postsynaptic Cytosol	Cytosol NADPH Oxidase Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Serine/threonine/tyrosine Kinase Activity ATP Binding Zinc Ion Binding	Protein Binding Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Enzyme Binding Rac GTPase Binding
	Biological Process	Protein Phosphorylation Chemical Synaptic Transmission Learning Or Memory Chemosensory Behavior Phosphorylation Peptidyl-serine Phosphorylation Platelet Activation Negative Regulation Of Protein Ubiquitination Regulation Of Response To Food Positive Regulation Of Mismatch Repair Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Regulation Of Circadian Rhythm Response To Morphine Negative Regulation Of Neuron Apoptotic Process Protein Autophosphorylation Response To Pain Rhythmic Process Regulation Of Phagocytosis Innervation Presynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Proteasomal Protein Catabolic Process Response To Psychosocial Stress Regulation Of Synaptic Vesicle Exocytosis	Superoxide Metabolic Process Regulation Of Hydrogen Peroxide Metabolic Process Superoxide Anion Generation Positive Regulation Of Catalytic Activity Regulation Of Respiratory Burst
Pathways		Calmodulin induced events Disinhibition of SNARE formation Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events WNT5A-dependent internalization of FZD4 Response to elevated platelet cytosolic Ca2+	RHO GTPases Activate NADPH Oxidases WNT5:FZD7-mediated leishmania damping
Drugs		Tamoxifen
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS			Response to fenofibrate (total cholesterol levels) ( 27002377)
Interacting Genes		65 interacting genes: AFAP1 ANXA7 APP ARHGEF25 ARHGEF7 CASR CCHCR1 CD5 CDC42 CHAT CTNNB1 CYTH2 DAB2 DDX58 DNAJC5 DVL2 EIF4E EPHB1 EXOC5 FBXO7 GABRA1 GABRA4 GFAP GJA1 GJA3 GRIA4 GRIN1 GRIN2B GRIN2D GRK2 GRM5 GSK3A HABP4 HSPA4 IRS1 ITGB2 MAPT MARK4 NOXA1 NRGN NUMB PA2G4 PABPC4 PARD3 PARD6A PARD6B PDLIM5 PEBP1 PICK1 PNMA1 PPP1R14A RANBP10 RGS2 SCN3A SDC2 SMURF1 STXBP1 TIAM1 TOP2A TRIM5 UBE2T VTN YWHAB YWHAE YWHAG	14 interacting genes: CACNA1A EP300 FAT1 MAPK1 MAPK11 NCF1 NOX1 NOXO1 PRKACA PRKCA PRKCG RAC1 RAC2 RIMBP3
Entrez ID		5582	10811
HPRD ID		01502	17644
Ensembl ID		ENSG00000126583	ENSG00000188747
Uniprot IDs		B2R5T1 B7Z3W6 P05129	Q86UR1
PDB IDs		2E73 2UZP
Enriched GO Terms of Interacting Partners?
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