CCDC88A and GNAI3

Number of citations of the paper that reports this interaction (PubMedID 26186194)
367

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology, pull down)

		CCDC88A	GNAI3
Description		coiled-coil domain containing 88A	G protein subunit alpha i3
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GO Annotations	Cellular Component	Cell Cytoplasm Endoplasmic Reticulum Golgi Apparatus Centrosome Centriole Cytosol Plasma Membrane Membrane Lamellipodium COPI-coated Golgi To ER Transport Vesicle Cytoplasmic Vesicle Ciliary Basal Body	Golgi Membrane Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Exosome
	Molecular Function	G-protein Alpha-subunit Binding Actin Binding Protein Kinase C Binding Guanyl-nucleotide Exchange Factor Activity GDP-dissociation Inhibitor Activity Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Microtubule Binding G-protein Gamma-subunit Binding Phosphatidylinositol Binding SH2 Domain Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 2 Binding Protein Kinase B Binding Dynein Light Intermediate Chain Binding	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Protein Phosphorylation DNA Replication Regulation Of DNA Replication Small GTPase Mediated Signal Transduction Regulation Of Neuron Projection Development Cell Migration Lamellipodium Assembly Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization TOR Signaling Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Regulation Of Actin Cytoskeleton Organization Regulation Of Cell Proliferation Positive Regulation Of Cilium Assembly Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Membrane Organization Maintenance Of Protein Location In Plasma Membrane Positive Regulation Of Protein Localization To Cilium	Protein Folding Vesicle Fusion Cell Cycle G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Dopamine Receptor Signaling Pathway Brain Development Positive Regulation Of Macroautophagy Positive Regulation Of Superoxide Anion Generation Positive Regulation Of NAD(P)H Oxidase Activity GTP Metabolic Process Cell Division Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway
Pathways			PLC beta mediated events PLC beta mediated events Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS		Height ( 21998595)	Major depressive disorder ( 20125088)
Interacting Genes		11 interacting genes: AKT1 BRAF DISC1 EGFR EXOC1 GNAI3 INSR KDR NDEL1 PRKACA PTPN6	41 interacting genes: AGTR2 ATP12A CCDC88A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 GNB2 GNB4 GPSM1 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR
Entrez ID		55704	2773
HPRD ID		11131	00765
Ensembl ID		ENSG00000115355	ENSG00000065135
Uniprot IDs		A0A2U3TZV9 O14997 Q3V6T2	P08754
PDB IDs		6MHF	2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S
Enriched GO Terms of Interacting Partners?
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