GNAI3 and NGB

Number of citations of the paper that reports this interaction (PubMedID 12860983)
56

Data Source:
HPRD (in vitro)

		GNAI3	NGB
Description		G protein subunit alpha i3	neuroglobin
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Zymogen Granule Membrane Raft Extracellular Exosome	Mitochondrion Cytosol Perikaryon
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding GTPase Activating Protein Binding Metal Ion Binding	Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Metal Ion Binding
	Biological Process	Protein Folding Vesicle Fusion Cell Cycle G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Dopamine Receptor Signaling Pathway Brain Development Positive Regulation Of Macroautophagy Positive Regulation Of Superoxide Anion Generation Positive Regulation Of NAD(P)H Oxidase Activity GTP Metabolic Process Cell Division Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway	Apoptotic Process Oxygen Transport
Pathways		PLC beta mediated events PLC beta mediated events Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production	Intracellular oxygen transport
Drugs
Diseases
GWAS		Major depressive disorder ( 20125088)
Interacting Genes		41 interacting genes: AGTR2 ATP12A CCDC88A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 GNB2 GNB4 GPSM1 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SOX30 TSHR	14 interacting genes: AKT1 ATP1B2 C1orf94 FLOT1 GNAI1 GNAI2 GNAI3 GNAO1 IHO1 L3MBTL3 PTEN REL TDO2 VAC14
Entrez ID		2773	58157
HPRD ID		00765	05602
Ensembl ID		ENSG00000065135	ENSG00000165553
Uniprot IDs		P08754	A0M8W9 Q9NPG2
PDB IDs		2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S	1OJ6 4MPM
Enriched GO Terms of Interacting Partners?
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