HIF1AN and ASB4

Number of citations of the paper that reports this interaction (PubMedID 26186194)
367

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid)
HPRD (in vivo)

		HIF1AN	ASB4
Description		hypoxia inducible factor 1 subunit alpha inhibitor	ankyrin repeat and SOCS box containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Cytosol Cul2-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Notch Binding Iron Ion Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Oxygen Sensor Activity Carboxylic Acid Binding Peptidyl-histidine Dioxygenase Activity Peptidyl-asparagine 3-dioxygenase Activity Protein Homodimerization Activity Cofactor Binding NF-kappaB Binding Ankyrin Repeat Binding Hypoxia-inducible Factor-asparagine Oxygenase Activity	Ubiquitin-protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Peptidyl-histidine Hydroxylation Peptidyl-aspartic Acid Hydroxylation Peptidyl-asparagine Hydroxylation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Notch Signaling Pathway Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Vasculogenesis	Intracellular Signal Transduction Post-translational Protein Modification Protein Autoubiquitination Positive Regulation Of Vasculogenesis
Pathways		Cellular response to hypoxia	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		D-tartaric acid N-(carboxycarbonyl)-D-phenylalanine
Diseases
GWAS		Body mass index ( 28892062 25673413) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Metabolite levels ( 23823483) Palmitoleic acid (16:1n-7) levels ( 28298293 23362303)	BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Metabolite levels ( 23823483) Middle childhood and early adolescence aggressive behavior ( 26087016)
Interacting Genes		14 interacting genes: ASB13 ASB4 ASB9 FBF1 HDAC1 HDAC2 HDAC3 HIF1A INVS NAA10 SIAH1 TP53BP2 UACA VHL	4 interacting genes: AKAP9 HIF1AN ID2 UBE2D1
Entrez ID		55662	51666
HPRD ID		09426	05770
Ensembl ID		ENSG00000166135	ENSG00000005981
Uniprot IDs		Q9NWT6	Q9Y574
PDB IDs		1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P 4AI8 4B7E 4B7K 4BIO 4JAA 4NR1 4Z1V 4Z2W 5JWK 5JWL 5JWP 5OP6 5OP8 5OPC 6H9J 6HA6 6HC8 6HKP 6HL5 6HL6
Enriched GO Terms of Interacting Partners?
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