NAGK and MTHFD2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		NAGK	MTHFD2
Description		N-acetylglucosamine kinase	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Image
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Extracellular Space Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding ATP Binding N-acetylglucosamine Kinase Activity	Magnesium Ion Binding Methenyltetrahydrofolate Cyclohydrolase Activity Methylenetetrahydrofolate Dehydrogenase (NAD+) Activity Methylenetetrahydrofolate Dehydrogenase (NADP+) Activity Phosphate Ion Binding
	Biological Process	N-acetylglucosamine Metabolic Process UDP-N-acetylglucosamine Biosynthetic Process N-acetylmannosamine Metabolic Process N-acetylneuraminate Catabolic Process Carbohydrate Phosphorylation	One-carbon Metabolic Process Tetrahydrofolate Interconversion Tetrahydrofolate Metabolic Process Folic Acid Metabolic Process Oxidation-reduction Process
Pathways		Synthesis of UDP-N-acetyl-glucosamine	Metabolism of folate and pterines
Drugs		N-Acetylglucosamine	Tetrahydrofolic acid NADH
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Erythema nodosum in inflammatory bowel disease ( 24487271)
Interacting Genes		32 interacting genes: ACTR10 CCDC158 CDKN2C CEP43 DACH1 DCP2 DYNC1I1 GNPNAT1 LACTB2 LENG1 LMO1 LNX1 LNX2 LSM8 MEOX1 MTHFD2 NTAQ1 PJA1 PKM PPHLN1 REL SDCBP SF3B3 SMAD2 SMAD9 SPRED1 SRPK2 STK16 SYNE4 TCF12 TNNT1 WDR82	4 interacting genes: DAPK1 LMNA NAGK PTEN
Entrez ID		55577	10797
HPRD ID		08441	05351
Ensembl ID		ENSG00000124357	ENSG00000065911
Uniprot IDs		A0A384N6G7 C9JEV6 Q9UJ70	P13995
PDB IDs		2CH5 2CH6	1ZN4 5TC4 6JIB 6JID 6KG2
Enriched GO Terms of Interacting Partners?
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