SOX6 and TRIP12

Number of citations of the paper that reports this interaction (PubMedID 23663701)
4

Data Source:
BioGRID (two hybrid, affinity chromatography technology, enzymatic study)

		SOX6	TRIP12
Description		SRY-box transcription factor 6	thyroid hormone receptor interactor 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytosol Nuclear Speck
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Thyroid Hormone Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis In Utero Embryonic Development Regulation Of Transcription, DNA-templated Central Nervous System Development Muscle Organ Development Post-embryonic Development Gene Silencing Spinal Cord Oligodendrocyte Cell Differentiation Oligodendrocyte Cell Fate Specification Positive Regulation Of Chondrocyte Differentiation Cell Fate Commitment Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Astrocyte Differentiation Erythrocyte Development Cartilage Development Cardiac Muscle Cell Differentiation Positive Regulation Of Cartilage Development Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Cardiac Muscle Cell Differentiation Positive Regulation Of Mesenchymal Stem Cell Differentiation	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Embryonic Development Negative Regulation Of Histone H2A K63-linked Ubiquitination Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair
Pathways		Deactivation of the beta-catenin transactivating complex	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 30395268) Anti-saccade response ( 25387707) Blond vs. brown/black hair color ( 30531825) Blood pressure ( 23972371) Bone mineral density ( 24249740) Bone mineral density (hip) ( 19801982) Bone mineral density (wrist) ( 21104366) Capecitabine sensitivity ( 22864933) Chronotype ( 30696823) Coronary artery disease ( 29212778) Cotinine glucuronidation ( 25293881) Diastolic blood pressure ( 27841878 25249183 30578418) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Experiencing mood swings ( 29500382) Femoral neck bone mineral density ( 29499414 26367794 22504420) General factor of neuroticism ( 30867560) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hypertension ( 25249183) Longevity (90 years and older) ( 25199915) Lumbar spine bone mineral density ( 26367794) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Multisite chronic pain ( 31194737) Neurociticism ( 29500382) Neuroticism ( 29255261) Obesity and osteoporosis ( 19714249) Pulse pressure ( 30578418) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Systolic blood pressure ( 27841878 25249183 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Tea consumption ( 31046077)	Estimated glomerular filtration rate ( 31152163 31015462) Metabolite levels ( 23823483) Systolic blood pressure ( 30224653) Weight ( 28552196)
Interacting Genes		12 interacting genes: CENPK CTBP2 DAZAP2 HDAC1 POMGNT1 SOX5 SUMO1 SUMO2 SUMO3 TRIP12 UBE2I ZNF184	20 interacting genes: ATF7IP CARNS1 CDKN2A CELSR3 CLSTN1 ERG MTNR1A MTNR1B NAE1 NMI PTF1A SMAD9 SOX6 SRPK2 THRB UBC UBE2D1 UBE2D2 UBE2L3 UBE4B
Entrez ID		55553	9320
HPRD ID		06267	05144
Ensembl ID		ENSG00000110693	ENSG00000153827
Uniprot IDs		P35712	Q14669
PDB IDs
Enriched GO Terms of Interacting Partners?
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