SOX6

Description		SRY-box transcription factor 6
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis In Utero Embryonic Development Regulation Of Transcription, DNA-templated Central Nervous System Development Muscle Organ Development Post-embryonic Development Gene Silencing Spinal Cord Oligodendrocyte Cell Differentiation Oligodendrocyte Cell Fate Specification Positive Regulation Of Chondrocyte Differentiation Cell Fate Commitment Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Astrocyte Differentiation Erythrocyte Development Cartilage Development Cardiac Muscle Cell Differentiation Positive Regulation Of Cartilage Development Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Cardiac Muscle Cell Differentiation Positive Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 30395268) Anti-saccade response ( 25387707) Blond vs. brown/black hair color ( 30531825) Blood pressure ( 23972371) Bone mineral density ( 24249740) Bone mineral density (hip) ( 19801982) Bone mineral density (wrist) ( 21104366) Capecitabine sensitivity ( 22864933) Chronotype ( 30696823) Coronary artery disease ( 29212778) Cotinine glucuronidation ( 25293881) Diastolic blood pressure ( 27841878 25249183 30578418) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Experiencing mood swings ( 29500382) Femoral neck bone mineral density ( 29499414 26367794 22504420) General factor of neuroticism ( 30867560) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hypertension ( 25249183) Longevity (90 years and older) ( 25199915) Lumbar spine bone mineral density ( 26367794) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Multisite chronic pain ( 31194737) Neurociticism ( 29500382) Neuroticism ( 29255261) Obesity and osteoporosis ( 19714249) Pulse pressure ( 30578418) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Systolic blood pressure ( 27841878 25249183 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Tea consumption ( 31046077)
Interacting Genes		12 interacting genes: CENPK CTBP2 DAZAP2 HDAC1 POMGNT1 SOX5 SUMO1 SUMO2 SUMO3 TRIP12 UBE2I ZNF184
Entrez ID		55553
HPRD ID		06267
Ensembl ID		ENSG00000110693
Uniprot IDs		P35712
PDB IDs
Enriched GO Terms of Interacting Partners?
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