SRGN and GZMB

Number of citations of the paper that reports this interaction (PubMedID 12388539)
19

Data Source:
HPRD (in vitro)

		SRGN	GZMB
Description		serglycin	granzyme B
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Secretory Granule Platelet Alpha Granule Lumen Mast Cell Granule Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Postsynaptic Specialization, Intracellular Component	Immunological Synapse Nucleus Cytoplasm Mitochondrion Cytosol Membrane
	Molecular Function	Protein Binding	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity
	Biological Process	Platelet Degranulation Granzyme-mediated Apoptotic Signaling Pathway Protein Processing Negative Regulation Of Bone Mineralization Biomineral Tissue Development Secretory Granule Organization Mast Cell Secretory Granule Organization T Cell Secretory Granule Organization Maintenance Of Protease Location In Mast Cell Secretory Granule Maintenance Of Granzyme B Location In T Cell Secretory Granule Negative Regulation Of Cytokine Secretion Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization	Proteolysis Apoptotic Process Granzyme-mediated Apoptotic Signaling Pathway Negative Regulation Of Translation Cytolysis Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		Platelet degranulation	NOTCH2 intracellular domain regulates transcription Activation, myristolyation of BID and translocation to mitochondria
Drugs
Diseases
GWAS		Glycemic traits (pregnancy) ( 23903356)	Blood protein levels ( 30072576 29875488) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Vitiligo ( 20410501 27723757)
Interacting Genes		13 interacting genes: ALB BAG6 CCL3 CD44 CEP70 FHL3 GZMB PF4 PSRC1 SGTA UBQLN1 UBQLN4 UBR4	27 interacting genes: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 NEK9 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6
Entrez ID		5552	3002
HPRD ID		01513	00476
Ensembl ID		ENSG00000122862	ENSG00000100453
Uniprot IDs		P10124	J3KQ52 P10144 Q67BC3 Q6XGZ4
PDB IDs			1FQ3 1IAU
Enriched GO Terms of Interacting Partners?
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