PPP3CC and SDC2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		PPP3CC	SDC2
Description		protein phosphatase 3 catalytic subunit gamma	syndecan 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Calcineurin Complex Glutamatergic Synapse Presynaptic Cytosol	Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Integral Component Of Membrane Lysosomal Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding Calmodulin Binding Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding	Protein Binding PDZ Domain Binding Identical Protein Binding
	Biological Process	Protein Dephosphorylation Brain Development Calcineurin-NFAT Signaling Cascade Calcineurin-mediated Signaling Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Retinoid Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Biological_process Cell Migration Post-translational Protein Modification Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway Dendrite Morphogenesis Regulation Of Dendrite Morphogenesis Leukocyte Migration
Pathways		Activation of BAD and translocation to mitochondria DARPP-32 events	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPHB-mediated forward signaling Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Retinoid metabolism and transport
Drugs			Sargramostim
Diseases
GWAS		General risk tolerance (MTAG) ( 30643258) HIV-1 viral setpoint ( 20205591) Verbal declarative memory ( 25648963)	Post-traumatic stress disorder ( 26114229)
Interacting Genes		11 interacting genes: AMPH APP BCL2 BMPR1B CABIN1 CSNK2B HAX1 ITPKC SDC2 TGFBR1 THAP7	27 interacting genes: ANOS1 BAG6 CASK CSF2 CYP2C18 EPHB2 EZR FGF2 FN1 HGF ITGB4 LAMA3 NF1 PF4 PPP3CC PRKCA PRKCB PRKCG REG3A SDCBP SERPINA1 SERPINC1 SPARC TGFB1 TGFBR3 TNFSF13 TRAPPC4
Entrez ID		5533	6383
HPRD ID		00236	00803
Ensembl ID		ENSG00000120910	ENSG00000169439
Uniprot IDs		P48454	A0A024R9D1 E9PBI9 P34741
PDB IDs			6ITH
Enriched GO Terms of Interacting Partners?
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