FANCI and FANCL

Number of citations of the paper that reports this interaction (PubMedID 27986371)
31

Data Source:
BioGRID (enzymatic study, enzymatic study, unspecified method, enzymatic study)

		FANCI	FANCL
Description		FA complementation group I	FA complementation group L
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Membrane	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Nuclear Body Intracellular Membrane-bounded Organelle Fanconi Anaemia Nuclear Complex
	Molecular Function	DNA Binding Protein Binding DNA Polymerase Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cell Cycle Positive Regulation Of Protein Ubiquitination Interstrand Cross-link Repair	DNA Repair Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Gamete Generation Interstrand Cross-link Repair Regulation Of Cell Proliferation
Pathways		Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes	Fanconi Anemia Pathway
Drugs
Diseases		Fanconi anemia	Fanconi anemia
GWAS		Height ( 25282103) Menopause (age at onset) ( 26414677)	Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 31453325 20935630) Body mass index variance ( 31453325) Childhood absence epilepsy ( 30531953) Chronotype ( 30696823) Epilepsy ( 25087078 30531953) Feeling miserable ( 29500382) Generalized epilepsy ( 30531953) Hirschsprung disease ( 27702942) Initial pursuit acceleration ( 29064472) Irritable mood ( 29500382) Obesity ( 23563607) Pre-treatment viral load in HIV-1 infection ( 31219150) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Schizophrenia ( 25056061 29483656) Smoking status (ever vs never smokers) ( 30643258) Tea consumption ( 31046077) Type 2 diabetes ( 30718926) Waist circumference ( 25673412) Waist-hip ratio ( 25673412)
Interacting Genes		13 interacting genes: AKT1 APP ATR BRCA2 FANCD2 FANCL MTDH MTNR1B PIAS1 RAD51 UBL5 USP1 WDR48	26 interacting genes: ACVR1 BMPR1B CHCHD3 CTBP1 DOCK8 EIF4ENIF1 FAAP100 FANCB FANCD2 FANCF FANCI GGN GRN HES1 IHO1 IKZF3 KIFC3 LZTS2 PCNA RBM45 RIMBP3 SSX2IP TFCP2 TGFBR1 UBE2T UBE2W
Entrez ID		55215	55120
HPRD ID		13339	06997
Ensembl ID		ENSG00000140525	ENSG00000115392
Uniprot IDs		B3KNW8 Q9NVI1	Q9NW38
PDB IDs			3ZQS 4CCG
Enriched GO Terms of Interacting Partners?
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