PPP1CC and NEK2

Number of citations of the paper that reports this interaction (PubMedID 21382349)
25

Data Source:
BioGRID (far western blotting, two hybrid)

		PPP1CC	NEK2
Description		protein phosphatase 1 catalytic subunit gamma	NIMA related kinase 2
Image
GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Condensed Chromosome Kinetochore Nuclear Chromosome, Telomeric Region Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Focal Adhesion Nuclear Speck Midbody Cleavage Furrow Protein-containing Complex Dendritic Spine PTW/PP1 Phosphatase Complex Presynapse Glutamatergic Synapse	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Microtubule Midbody Protein-containing Complex
	Molecular Function	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Lamin Binding Protein C-terminus Binding Protein Phosphatase 1 Binding Phosphatase Activity Protein Kinase Binding Protein Domain Specific Binding Protein-containing Complex Binding Metal Ion Binding Protein N-terminus Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding Metal Ion Binding
	Biological Process	Glycogen Metabolic Process Protein Dephosphorylation Cell Cycle Neuron Differentiation Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Regulation Of Nucleocytoplasmic Transport Cell Division Positive Regulation Of Glial Cell Proliferation	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Blastocyst Development Protein Phosphorylation Chromosome Segregation Regulation Of Mitotic Nuclear Division Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Binding Regulation Of Mitotic Centrosome Separation Protein Autophosphorylation Spindle Assembly Centrosome Separation Cell Division Meiotic Cell Cycle Positive Regulation Of Telomerase Activity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Assembly Ciliary Basal Body-plasma Membrane Docking Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Telomere Capping
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Triglyceride catabolism Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Circadian Clock RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	APC-Cdc20 mediated degradation of Nek2A Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs		9,10-Deepithio-9,10-Didehydroacanthifolicin Calyculin A Motuporin	5-[(Z)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE
Diseases
GWAS		Heart rate ( 23583979)	Red cell distribution width ( 27863252 28957414)
Interacting Genes		121 interacting genes: AATK ABT1 ACAD8 AKAP11 ANKRD42 APIP APP ASH2L AURKA B4GAT1 BMPR2 BTBD10 C1QA C9orf50 CEP126 CLMN CLOCK CLTC CNST COPS5 CSNK1A1 CSNK1E CSNK2B CSRNP1 CSRNP2 CTSL CYFIP1 DACT1 DEAF1 DELEC1 DYRK4 EIF2AK2 ELP4 ENKD1 FBXW11 FTL FXYD6 GLB1L GOLGA7 GSTZ1 HCFC1 HDAC6 HMGN1 IFTAP IL3RA INSYN1 JAK2 KCTD20 KDM4D KRCC1 LMTK2 MAP4K4 MAPT MYO16 NAPEPLD NEK2 NMT2 NONO NRBP1 NUAK1 PHACTR4 PHC1 PIAS1 PPP1R15B PPP1R16A PPP1R18 PPP1R2 PPP1R2B PPP1R32 PPP1R35 PPP1R3D PPP1R8 PPP1R9B PPP2R5C PRR16 RAF1 RB1 RIF1 RNF19B RORC RPL7 RPRD2 RRM1 RRP1B SDR39U1 SFRP1 SGCE SH3RF2 SHANK3 SMARCB1 SMG6 SPATC1L SPOCD1 STAM STARD9 STAU1 TACC2 TBC1D19 TCTEX1D4 TEFM TEX36 TLX1 TLX3 TMEM120A TNS1 TOPBP1 TOR1AIP1 TP53 TP53BP2 TPRN TRA2A TWISTNB VSTM4 WBP11 YLPM1 YWHAZ ZDBF2 ZFYVE9 ZNF24 ZNF318 ZNF667	28 interacting genes: CCDC85A CDC20 CEP250 CHGA CSN2 CTNNB1 DCTN1 EDRF1 EIF4A2 FZR1 GIT1 IFT140 IMMT MAD1L1 MAPK1 MCC NDC80 NEK11 PDE4DIP PPP1CA PPP1CC PPP1R2 PRKN PTPRD SMURF1 SPTBN4 TCF25 TPM3
Entrez ID		5501	4751
HPRD ID		08911	04953
Ensembl ID		ENSG00000186298	ENSG00000117650
Uniprot IDs		A0A024RBP2 P36873	F6U4U2 P51955
PDB IDs		1IT6 1JK7 1U32 2BCD 2BDX 4UT2 4UT3 5INB 5J28	2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP 4A4X 4AFE 5M51 5M53 5M55 5M57 6H0O
Enriched GO Terms of Interacting Partners?
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