NEK2 and NEK11

Number of citations of the paper that reports this interaction (PubMedID 15161910)
12

Data Source:
HPRD (in vitro, in vivo)

		NEK2	NEK11
Description		NIMA related kinase 2	NIMA related kinase 11
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Microtubule Midbody Protein-containing Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding Metal Ion Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Blastocyst Development Protein Phosphorylation Chromosome Segregation Regulation Of Mitotic Nuclear Division Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Binding Regulation Of Mitotic Centrosome Separation Protein Autophosphorylation Spindle Assembly Centrosome Separation Cell Division Meiotic Cell Cycle Positive Regulation Of Telomerase Activity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Assembly Ciliary Basal Body-plasma Membrane Docking Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Telomere Capping	Protein Phosphorylation Chromosome Segregation Histone Phosphorylation Intra-S DNA Damage Checkpoint Intracellular Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		APC-Cdc20 mediated degradation of Nek2A Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs		5-[(Z)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE	Dabrafenib
Diseases
GWAS		Red cell distribution width ( 27863252 28957414)	Carotid intima media thickness ( 26343869) Hippocampal sclerosis ( 25188341) Phenylephrine infusion rate during anesthesia ( 31455332) Weight ( 28552196)
Interacting Genes		28 interacting genes: CCDC85A CDC20 CEP250 CHGA CSN2 CTNNB1 DCTN1 EDRF1 EIF4A2 FZR1 GIT1 IFT140 IMMT MAD1L1 MAPK1 MCC NDC80 NEK11 PDE4DIP PPP1CA PPP1CC PPP1R2 PRKN PTPRD SMURF1 SPTBN4 TCF25 TPM3	5 interacting genes: APP BLM MFHAS1 MYC NEK2
Entrez ID		4751	79858
HPRD ID		04953	14821
Ensembl ID		ENSG00000117650	ENSG00000114670
Uniprot IDs		F6U4U2 P51955	B4DDN2 B4DM56 E9PHI8 Q8NG66
PDB IDs		2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP 4A4X 4AFE 5M51 5M53 5M55 5M57 6H0O
Enriched GO Terms of Interacting Partners?
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